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Frequency, pathogenicity and microbiologic outcome of non-Candida albicans candiduria

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Abstract

A retrospective review of urine cultures obtained from patients at the University of Illinois Hospital revealed that the frequency of isolation of non-albicans Candida species increased significantly from 1990 to 1991 (p=0.0003), while the frequency of isolation ofCandida albicans species decreased significantly (p=0.0006). Patients with urine cultures positive for non-albicans Candida species orTorulopsis glabrata during 1991 were identified for review. Sixty-seven patients were eligible for evaluation. Non-albicans candiduria developed in an average of 12 days. Identical fungal species were isolated from the blood following a positive urine culture in only two patients. Twenty patients were treated; candiduria persisted in 9 (45 %), while resolution occurred in 11 (55 %). The remaining 47 patients were not treated. Non-albicans candiduria persisted in 30 (64 %) of these patients and resolved in 15 (32 %); in the remaining two patients (4 %) the microbiologic outcome was undetermined. The difference in microbiologic outcomes between treated and untreated patients was not significant using the Chi-square test (p=0.170). Non-albicans candiduria developed rapidly, frequently persisted whether treated or untreated, and rarely progressed to candidemia.

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Authors and Affiliations

  1. Department of Medicine, University of Illinois at Chicago, 833 S. Wood Street, 60612, Chicago, Illinois, USA

    L. H. Danziger

  2. Department of Pathology, University of Illinois at Chicago, 833 S. Wood Street, 60612, Chicago, Illinois, USA

    P. Schreckenberger

  3. Department of Pharmacy Practice M/C 886, Colleges of Pharmacy and Medicine, University of Illinois at Chicago, 833 S. Wood Street, 60612, Chicago, Illinois, USA

    D. J. Occhipinti & L. H. Danziger

  4. Department of Pharmacy Practice, College of Pharmacy, University of Arkansas Medical Sciences Center, Little Rock, Arkansas, USA

    P. O. Gubbins

Authors
  1. D. J. Occhipinti
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  2. P. O. Gubbins
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  3. P. Schreckenberger
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  4. L. H. Danziger
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Occhipinti, D.J., Gubbins, P.O., Schreckenberger, P. et al. Frequency, pathogenicity and microbiologic outcome of non-Candida albicans candiduria. Eur. J. Clin. Microbiol. Infect. Dis. 13, 459–467 (1994). https://doi.org/10.1007/BF01974635

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