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False positive widal reaction in high-titer disseminated BCG infection

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Abstract

False-positive Widal reactions following certain non-typhoidSalmonella infections may occur commonly. The case of a patient who developed miliary tuberculosis secondary to intravesical bacillus Calmette-Guérin (BCG) immunotherapy for bladder carcinoma is described. Very high titers of typhoid and paratyphoid agglutinins were obtained with the Widal test; these titers returned to normal after successful anti-tuberculous treatment. This case of high-titer, false-positiveSalmonella typhi andSalmonella paratyphi A and B reactions to BCG infection occurred in an area non-endemic for typhoid or paratyphoid fever.

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References

  1. Schroeder SA Interpretation of serologic tests for typhoid fever. Journal of the American Medical Association 1968, 206: 839–840.

    Article  PubMed  Google Scholar 

  2. Reynolds DW, Carpenter R, Simon WH Diagnostic specificity of Widal's reaction for typhoid fever. Journal of the American Medical Association 1970, 214: 2192–2193.

    Article  PubMed  Google Scholar 

  3. Senewiratne B, Chir B, Senewiratne K Reassessment of the Widal test in the diagnosis of typhoid. Gastroenterology 1977, 73: 233–236.

    PubMed  Google Scholar 

  4. Mohammed I, Chikwem JO, Gashan W Determination of Widal agglutination of the baseline titre for the diagnosis of typhoid fever in two Nigerian states. Scandinavian Journal of Immunology 1992, 36, Supplement 11: 153–156.

    Google Scholar 

  5. Chew SK, Cruz MS, Lim YS, Monteiro EH Diagnostic value of the Widal test for typhoid fever in Singapore. Journal of Tropical Medicine and Hygiene 1992, 95: 288–291.

    PubMed  Google Scholar 

  6. Aquino RL, Lansang MA, Quimpo VS, Sombrero LT, Saniel MC Evaluation of a single Widal test in the diagnosis of enteric fever. Southeastern Asian Journal of Tropical Medicine and Public Health 1991, 22: 375–379.

    Google Scholar 

  7. Koeleman JGM, Regensburg DF, Van Katwijk F, MacLaren DM Retrospective study to determine the diagnostic value of the Widal test in a non-endemic country. European Journal of Clinical Microbiology and Infectious Diseases 1992, 11: 167–170.

    Article  Google Scholar 

  8. Onuigbo MA Diagnosis of typhoid fever in Nigeria: misuse of the Widal test. Transactions of the Royal Society of Tropical Medicine and Hygiene 1990, 84: 129–131.

    Article  PubMed  Google Scholar 

  9. Widal F Serodiagnostic de la fievre typhoide a propos d'une modification par M.M.C. Nicolle et A. Halipze. Bulletin et Memoire de la Societe Medicale des Hopiteaux Paris 1896, 13: 561–566.

    Google Scholar 

  10. Samal KK, Sahu CS Malaria and Widal reaction. Journal of Association of Physicians of India 1991, 39: 745–747.

    Google Scholar 

  11. Wicks ACB, Holmes GS, Davidson L Endemic typhoid fever — a diagnostic pitfall. Quarterly Journal of Medicine 1971, 40: 341–354.

    PubMed  Google Scholar 

  12. Protell RL, Soloway RD, Schoenfield LJ Antisalmonella agglutinins in chronic active liver disease. Lancet 1971, ii: 330–331.

    Article  Google Scholar 

  13. Hillyard RW, Ladaga L, Schellhammer PF Superficial transitional cell carcinoma of the bladder associated with mucosal involvement of the prostatic urethra: results of treatment with intravesical bacillus Calmette-Guérin. Journal of Urology 1988, 139: 290–293.

    PubMed  Google Scholar 

  14. Lamm DL Systemic bacillus Calmette-Guérin infection after transurethral administration for superficial bladder carcinoma. Editorial comment. Journal of Urology 1989, 142: 1073–1075.

    PubMed  Google Scholar 

  15. Kunin CM Separation, characterization and biological significance of a common antigen inEnterobacteriaceae. Journal of Experimental Medicine 1963, 118: 565–586.

    Article  PubMed  Google Scholar 

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Skoutelis, A., Dimitrakopoulos, G. & Bassaris, H. False positive widal reaction in high-titer disseminated BCG infection. Eur. J. Clin. Microbiol. Infect. Dis. 13, 261–263 (1994). https://doi.org/10.1007/BF01974548

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