Abstract
A decrease in mechanical strength of bones was observed both in young and old rats for long periods of administration of cadmium. Young (3-week-old) female rats were given 0 (control), 5 and 10 ppm cadmium in drinking water, respectively, for 20 weeks. Old (18-month old) female rats were given 0 (control) and 40 ppm cadmium in drinking water, respectively, for 7 months. The compression strengths of bones of young rats which were given 10 ppm cadmium, and those of old rats which were given 40 ppm cadmium, significantly decreased at the distal end portion of femur. Cadmium contents in bones in the 10 ppm and 40 ppm groups were about 110 and 210 ng/g dry weight, respectively. The present result confirmed that cadmium has a lesional effect on the mechanical strength of bone at the concentration of 100–200 ng/g in dry weight of bone, for both young and old rats.
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References
Bonner FW, King LJ, Parke DV (1980) The effect of dietary cadmium on zinc, copper and iron levels in the bone of rats. Toxicol Lett 5: 105–108
Friberg L, Piscator M, Nordberg GF, Kjellstroem T (1974) In: Cadmium in the environment. CRC Press, Cleveland, Ohio, p 114
Iguchi H, Sano S (1982) Effect of cadmium on the bone collagen metabolism of rat. Toxicol Appl Pharmacol 62: 126–136
Itokawa Y, Abe T, Tabei R, Tanaka S (1974) Renal and skeletal lesions in experimental cadmium poisoning. Arch Environ Health 28: 149–154
Kawai K, Fukuda K, Kimura M (1976) Morphological alterations in experimental cadmium exposure with special reference to the onset of renal lesion. In: Nordberg GF (ed) Effects and dose-response relationships of toxic metals. Elsevier Scientific Publishing Co, Amsterdam, pp 343–370
Kimura M, Otaki N, Yoshiki S, Suzuki M, Horiuchi N, Suda T (1974) The isolation of metallothionein and its protective role in cadmium poisoning. Arch Biochem Biophys 165: 340–348
Krishnan SS, Harrison JE, Jervis RE, Hitchman AJW, Dowlati R, Lui SMW, Krishnan B (1988) Studies of skeletal cadmium assay and toxicity. J Radioanal Nucl Chem 124: 79–84
Kucharz EJ (1988) Effect of cadmium intoxication on collagen and elastin content in tissues of the rat. Bull Environ Contam Toxicol 40: 273–279
Nagai Y, Sato M, Sasaki M (1982) Effect of cadmium administration upon urinary excretion of hydroxylisine and hydroxyproline in the rat. Toxicol Appl Pharmacol 63: 188–193
Ogoshi K (1985) Effects of cadmium on the mechanical strength of rat bones. Jpn J Hyg 40: 745–755
Ogoshi K, Aoki Y, Kurumatani N, Moriyama T, Nanzai Y (1981) The changes in mechanical properties of rat bones under the low dose level of cadmium (I) the compressive strength. Jpn J Hyg 36: 584–595
Ogoshi K, Iwami K, Moriyama T, Nanzai Y (1984) The changes in mechanical properties of rat bones under the low dose level of cadmium (II) the torsional strength. Jpn J Hyg 39: 848–854
Ogoshi K, Moriyama T, Nanzai Y (1989) Decrease in the mechanical strength of bones of rats administered cadmium. Arch Toxicol 63: 320–324
Ogoshi K, Moriyama T, Nanzai Y (1990) Effect of cadmium on bones: studies on the mechanical strength of rat bones and the electron probe micro-analysis. Toxicol Environ Chem 27: 97–103
Sugawara C, Sugawara N (1983) Decrease and recovery of serum zinc and bone growth of rats with chronic ingestion of 25 ppm and 50 ppm cadmium. Toxicol Lett 15: 95–103
Tohyama C, Sugihara N, Saito H (1987) Critical concentration of cadmium for renal toxicity in rats. J Toxicol Environ Health 22: 255–259
Yoshiki S, Yanagisawa T, Kimura M, Otaki N, Suzuki M, Suda T (1975) Bone and kidney lesions in experimental cadmium intoxication. Arch Environ Health 30: 559–562
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Ogoshi, K., Nanzai, Y. & Moriyama, T. Decrease in bone strength of cadmium-treated young and old rats. Arch Toxicol 66, 315–320 (1992). https://doi.org/10.1007/BF01973625
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DOI: https://doi.org/10.1007/BF01973625