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The anti-inflammatory activity of marine natural products-6-n-tridecylsalicylic acid, flexibilide and dendalone 3-hydroxybutyrate

  • Immunosuppression and Inflammation
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Abstract

Three novel marine substances, 6-n-tridecylsalicylic acid, flexibilide and dendalone 3-hydroxybutyrate, isolated from a brown alga, a soft coral and a dictyoceratid sponge respectively, were active after oral administration in both acute and chronic animal models of inflammation. 6-n-Tridecylsalicylic acid has similar anti-inflammatory activity but less ulcerogenic activity on a molar basis than salicylic acid. The structure and activity of flexibilide did not resemble any known anti-inflammatory substance. Dendalone 3-hydroxybutyrate was a potent inhibitor of prostaglandin synthetase activity and platelet aggregation in vitro.

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Author notes

  1. K. M. Taylor

    Present address: Department of Pharmacology and Clinical Pharmacology, School of Medicine, University of Auckland, Auckland, New Zealand

Authors and Affiliations

  1. Roche Research Institute of Marine Pharmacology, 2099, Dee Why, New South Wales, Australia

    P. J. Buckle, B. A. Baldo & K. M. Taylor

Authors
  1. P. J. Buckle
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  2. B. A. Baldo
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  3. K. M. Taylor
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Buckle, P.J., Baldo, B.A. & Taylor, K.M. The anti-inflammatory activity of marine natural products-6-n-tridecylsalicylic acid, flexibilide and dendalone 3-hydroxybutyrate. Agents and Actions 10, 361–367 (1980). https://doi.org/10.1007/BF01971441

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  • DOI: https://doi.org/10.1007/BF01971441

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