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Activity of cefotiam in combination with beta-lactam antibiotics on enterobacterial hospital strains

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Abstract

By using checkerboard titrations the effect of cefotiam combined with different beta-lactam antibiotics on fifty strains of Enterobacteriaceae moderately susceptible (minimal inhibiting concentration ⩾8 mg/l) or resistant (minimal inhibiting concentration ⩾64 mg/l) to cefotiam was evaluated. The following compounds were tested: cefamandole, cefazolin, cefmenoxime, cefotaxime, cefotiam, ceftazidime, cefuroxime, mecillinam and piperacillin. The synergistic effect varied markedly. The combination cefotiam—mecillinam showed the highest rate of synergistic activity. Antagonism was found in 1% of the combinations.

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Authors and Affiliations

  1. Unit of Antibiotic Research, Institute Pasteur of Brabant, Engelandstraat 642, B-1180, Brussels, Belgium

    R. Vanhoof, H. J. Nyssen, E. Nulens, J. Leger,  N. de Schepper & M. L. Couvreur

  2. Department of Clinical Microbiology, J. Bracops Hospital, Dr. Huetstraat 79, B-1070, Brussels, Belgium

    J. M. Hubrechts

  3. Roussel SA, Ad. La Comblélaan 5965, B-1040, Brussels, Belgium

    E. Kupperberg

Authors
  1. R. Vanhoof
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  2. J. M. Hubrechts
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  3. H. J. Nyssen
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  4. E. Nulens
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  5. J. Leger
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  6. N. de Schepper
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  7. E. Kupperberg
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  8. M. L. Couvreur
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Vanhoof, R., Hubrechts, J.M., Nyssen, H.J. et al. Activity of cefotiam in combination with beta-lactam antibiotics on enterobacterial hospital strains. Pharmaceutisch Weekblad Scientific Edition 12, 104–106 (1990). https://doi.org/10.1007/BF01967603

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  • DOI: https://doi.org/10.1007/BF01967603

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