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Histamine and immune reactions. 3. Inhibition of early events of human lymphocyte activation by histamine

  • Histamine and Immunology
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Abstract

Histamine inhibits the chemiluminescence response of human lymphocytes to Concanavalin A by interfering with early triggering events. The inhibition seems to be mediated via H2 receptors, acts immediately, and is reversible by washing. A longer incubation in a histamine-containing medium induces a refractory state of the cells. The inhibitory effect described here is compared with the inhibitory action of histamine in the lymphocyte transformation test.

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Authors and Affiliations

  1. Division of Clinical Immunology, Humboldt University Department of Medicine (Charité), DDR-1040, Berlin

    P. Falck, D. Volk & S. Schnitzler

Authors
  1. P. Falck
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  2. D. Volk
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  3. S. Schnitzler
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In memoriam Dr S. Schnitzler.

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Falck, P., Volk, D. & Schnitzler, S. Histamine and immune reactions. 3. Inhibition of early events of human lymphocyte activation by histamine. Agents and Actions 13, 234–236 (1983). https://doi.org/10.1007/BF01967340

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  • DOI: https://doi.org/10.1007/BF01967340

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