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Structure of victorin C, the major host-selective toxin from Cochliobolus victoriae

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Summary

The predominant host-selective toxin fromCochliobolus victoriae, victorin C, is a peptide with an apparent mol. wt of 796, representing a cyclic array of the subunits1–6. The structure of the toxin has now been established as in16 through analysis of the degradation products generated by enzymic and non-enzymic partial hydrolysis. The presence of a hydrated aldehydo group requires for victorin C the composition C31H45O13N6Cl3 with an amended mol. wt of 814, for which independent experimental support has been secured.

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References

  1. Wheeler, H., and Luke, H. H., Microbial toxins in plant disease. A. Rev. Microbiol.17 (1963) 232–243.

    Article  Google Scholar 

  2. Meehan, F., and Murphy, H. C., A newHelminthosporium blight of oats. Science104 (1946) 413–414.

    Article  PubMed  Google Scholar 

  3. Meehan, F., and Murphy, H. C., Differential phytotoxicity of metabolic by-products ofHelminthosporium victoriae. Science106 (1947) 270–271.

    Article  CAS  PubMed  Google Scholar 

  4. Scheffer, R. P., Host-specific toxins in relation to pathogenesis and disease resistance, in: Encyclopedia of Plant Physiology, New Series, Vol. 4, pp. 245–269. Eds R. Heitefuss and P. H. Williams. Springer Verlag, Berlin-Heidelberg-New York 1976.

    Google Scholar 

  5. Macko, V., Wolpert, T. J., Acklin, W., Jaun, B., Seibl, J., Meili, J., and Arigoni, D., Characterization of victorin C, the major host-selective toxin fromCochliobolus victoriae: structure of degradation products. Experientia41 (1985) 1366–1370.

    Article  CAS  Google Scholar 

  6. For independent isolations of a toxic fraction fromC. victoriae which is probably identical with victorin C, cf. Keen, N. T., Midland, S., and Sims, J., Purification of victorin. Phytopathology73 (1983) 830 (Abstr.), and Walton, J. D., and Earle, E. D., Characterization of the host-specific phytotoxin victorin by high pressure chromatography. Pl. Sci. Lett.34 (1984) 231–238.

    Google Scholar 

  7. Chapman, G. E., Abercombie, B. D., Cary, P. D., and Bradbury, E. M., The measurement of small nuclear Overhauser effects in the1H spectra of proteins, and their application to lysozyme. J. Magn. Reson.31 (1978) 459–469.

    CAS  Google Scholar 

  8. Neuhaus, D., A method for the suppression of selective population transfer effects in NOE difference spectra. J. Magn. Reson.53 (1983) 109–114.

    CAS  Google Scholar 

  9. Fischer, G., Sieber, M., and Schellenberger, A., The carbonyl reactivity of 3-bromopyruvate and related compounds. Bioorg. Chem.11 (1982) 478–484.

    Article  CAS  Google Scholar 

  10. Anderson, G. W., Zimmermann, j. E., and Callahan, F. M., The use of esters of N-hydroxysuccinimide in peptide synthesis. J. Am. Chem. Soc.86 (1964) 1839–1842.

    Article  CAS  Google Scholar 

  11. 1H- and13C-NMR data matching very closely the critical ones of victorin C have been reported for the hydrate of glyoxylylspermidine by G. A. Ellestad, D. B. Cosulich, R. W. Broschard, J. H. Martin, M. P. Kunstmann, G. O. Morton, J. E. Lancaster, W. Fulmor and F. M. Lovell, Glycocinnamoylspermidines, a new class of antibiotics: 3. The structure of LL-BM 123 β, γ1, and γ2. J. Am. chem. Soc.100 (1978) 2515–2524.

    Article  CAS  Google Scholar 

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Wolpert, T.J., Macko, V., Acklin, W. et al. Structure of victorin C, the major host-selective toxin from Cochliobolus victoriae. Experientia 41, 1524–1529 (1985). https://doi.org/10.1007/BF01964789

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