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Prostanoids as second messengers of polypeptide growth factors

  • Lipid Mediators and Anti-Inflammatory Molecules
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Abstract

Prostaglandin H synthase (PGHs), also known as cyclooxygenase, is an unstable enzyme whose mRNA has an half life of 10 minutes. Some polypeptide factors have been reported to induce the enzyme in target cells. We have purified and characterized a component of animal sera which behaves as a potent inducer of human monocyte PGHs. This factor. called serum monocytotropic factor, has been identified in human platelets and it appcars to be structurally and biochemically different from identified platelet factors, such as platelet derived growth factor (PDGF) and transforming growth factor beta (TGF-beta), while showing strong similarities to colony stimulating factor 1 (CSF-1), so far undetected in platclets. Morcover, we have shown, by immunoblot analysis, that CSF-1 behaves as a potent and specific induccr of monocyte PGHs.

The hypothesis that prostanoids may be considered as second messengers of platelet CSF-1 like factor, as well as of other growth factors and that PGHs induction plays a pivotal role in this process, will be illustrated.

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Authors and Affiliations

  1. Department of Experimental Biology, University of Bologna, V. Belmeloro 8, 40126, Bologna, Italy

    G. Bartolini, M. Orlandi, L. Minghetti & V. Tomasi

  2. Department of Experimental Pathology, University of Bologna, V. S. Giacomo 12, 40126, Bologna, Italy

    F. Licastro & M. Chiricolo

  3. Institutc of General Pathology, University of Modena, V. Campi 287, 4100, Modena, Italy

    C. Franceschi

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  1. C. Franceschi
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Franceschi, C., Bartolini, G., Orlandi, M. et al. Prostanoids as second messengers of polypeptide growth factors. Agents and Actions 29, 39–47 (1990). https://doi.org/10.1007/BF01964715

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