Abstract
Florphenicol was active at a lower concentration than chloramphenicol against over half of 234 recent clinical bacterial isolates. The majority (98 %) of the isolates were inhibited by florphenicol at a concentration of 8 mg/l or less. Florphenicol was particularly effective against chloramphenicol resistant strains ofHaemophilus influenzae, Klebsiella aerogenes andBacteroides spp. Florphenicol was bacteristatic for salmonellae andEscherichia coli but bactericidal forHaemophilus influenzae. Florphenicol was slightly more active than chloramphenicol againstChlamydia trachomatis, Mycoplasma hominis andMycoplasma pneumoniae but less active againstUreaplasma urealyticum.
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Kucers, A., Bennett, N. M. Chloramphenicol and thiamphenicol. In: Kueers, A., Bennett, N. M. (ed.): The use of antibiotics. William Heinemann, London, 1979, p. 420–456.
Shears, P., Hart, C. A., Broadhead, R. L., Coulter, J. B. S. A note on antibiotic resistance inEscherichia coli isolated from children with diarrhoea in the Sudan. Annals of Tropical Paediatrics 1987, 7: 38–41.
Philpott-Howard, J., Williams, J. D. Increase in antibiotic resistance inHaemophilus influenzae in the United Kingdom since 1977: report of a study group. British Medical Journal 1982, 284: 1597–1601.
Fraise, A. P., Meeks, A. C. G., Richards, J. E. Meningitis due toHaemophilus influenzae resistant to ampicillin and chloramphenicol. Archives of Disease in Childhood 1986, 61: 1134–1135.
Yunis, A. A. Chloramphenicol-induced bone marrow suppression. Seminars in Haemotology 1973, 10: 225–234.
Hart, C. A., Percival, A. Resistance to cephalosporins among gentamicin-resistant klebsiellae. Journal of Antimicrobial Chemotherapy 1982, 9: 275–286.
How, S. J., Hobson, D., Hart, C. A., Quayle, E. A comparison of the in vitro activity of antimicrobials againstChlamydia trachomatis examined by Giemsa and fluorescent antibody stain. Journal of Antimicrobial Chemotherapy 1985, 15: 399–404.
Taylor-Robinson, D., Furr, P. M. The static effect of rosaramicin onUreaplasma urealyticum and the development of antibiotic resistance. Journal of Antimicrobial Chemotherapy 1982, 10: 185–191.
Britz, M. L., Wilkinson, R. G. Chloramphenicol acetyltransferase ofBacteroides fragilis. Antimicrobial Agents and Chemotherapy 1978, 14: 105–111.
Rowe, B., Threlfall, E. J., Ward, L. R. Does chloramphenicol remain the drug of choice for typhoid? Epidemiology and Infection 1987, 98: 379–383.
Shears, P., Suliman, G., Hart, C. A. Occurrence of multiple antibiotic resistance and R-plasmids inEnterobacteriaceae isolated from children in Sudan. Epidemiology and Infection 1988, 100: 73–81.
Syriopoulou, V. P., Harding, A. L., Goldmann, D. A., Smith, A. L. In vitro antibacterial activity of fluorinated analogues of chloramphenicol and thiamphenicol. Antimicrobial Agents and Chemotherapy 1981, 19: 294–297.
Neu, H. C., Fu, K. P., Kung, K. Fluorinated chloramphenicol analogs active against bacteria resistant to chloramphenicol. In: Nelson, J. D., Grassi, C. (ed.): Current Chemotherapy and Infectious Disease. American Society for Microbiology, Washington, DC, 1980, p. 446–447.
Keiser, G. Co-operative study of patients treated with thiamphenicol. Comparative study of patients treated with chloramphenicol and thiamphenicol. Postgraduate Medical Journal 1974, 50, Supplement 5: 143–149.
Garrod, L. P., Lambert, H. P., O'Grady, F.: Chloramphenicol. In: Garrod, L. P., Lambert, H. P., O'Grady, F. (ed.): Antibiotics and Chemotherapy. Churchill Livingstone, Edinburgh, p. 155–168.
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Graham, R., Palmer, D., Pratt, B.C. et al. In vitro activity of florphenicol. Eur. J. Clin. Microbiol. Infect. Dis. 7, 691–694 (1988). https://doi.org/10.1007/BF01964257
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DOI: https://doi.org/10.1007/BF01964257