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Inhibition by tryptophan of nucleolar RNA synthesis in salivary gland nuclei ofChironomus thummi

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Summary

Tryptophan, but not glutamine and lysine, inhibits the incorporation of3H-uridine into nucleoli of explanted salivary glands by about 60%. In isolated nuclei also, the nucleolar incorporation of3H-uridine triphosphate is reduced to about 50% by tryptophan. It is concluded that tryptophan acts directly at the nuclear level and the possible mechanisms involved are discussed.

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Authors and Affiliations

  1. Department of Botany, University of Nairobi, P.O. Box 30197, Nairobi, Kenya

    H. N. B. Gopalan & M. Robert

  2. Institut für Genetik, Universität des Saarlandes, D-66, Saarbrücken, Federal Republic of Germany

    H. N. B. Gopalan & M. Robert

Authors
  1. H. N. B. Gopalan
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  2. M. Robert
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Additional information

Acknowledgment. We are grateful to Prof. H. Kroeger for providing the facilities and help which have made this work possible, as well as to Dr M. Ashburner and Mr P. Kurth for going through the manuscript. H.N.B.G. is thankful to the DAAD, Bonn-Bad Godesberg, for financial support.

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Gopalan, H.N.B., Robert, M. Inhibition by tryptophan of nucleolar RNA synthesis in salivary gland nuclei ofChironomus thummi . Experientia 35, 1501–1503 (1979). https://doi.org/10.1007/BF01962810

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  • DOI: https://doi.org/10.1007/BF01962810

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