Abstract
Bradycardia, an extremely rare side-effect of ranitidine therapy is described in a 4-day-old full-term male neonate, who was admitted because of massive gastro-intestinal bleeding. Two hours after the intravenous injection of 1 mg/kg body weight per day, ECG showed sinus bradycardia of 60 beats/min with normal axis and QRS complex.The bradycardia gradually resolved in the next 24 h.
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Balestrazzi P, Gregori G, Bernasconi S, Giovannelli G (1985) Bradycardia and neurologic disorders associated with ranitidine in a child. Am J Dis Child 139:442
Cammarri E, Chirone E, Fanteria G, Zocchi M (1982) Ranitidine induced bradycardia. Lancet II:160
Drea EJ, Mutnick AH, Lam W, Palazzolo DP (1990) Cimetidine associated adverse reaction. An Pharmacother 24:581–583
Hart AM (1989) Cardiac arrest associated with ranitidine. BMJ 299:519
Hinrichsen H, Halabi A, Kirch W (1990) Hemodynamic effects of different H2 receptor antogonists. Clin Pharmacol Ther 48:302–308
Hughes DG, Dowling EA, DeMeersman RE, Garnett WR, Karmes HT (1989) Cardiovascular effects of H2-receptor antagonists. J Clin Pharmacol 29:472–477
Johnson WS, Miller DR (1988) Ranitidine and bradycardia. Ann Intern Med 108:493
Keitoku M, Maruyama Y, Takishima T (1990) Different histamine actions in proximal and distal human coronary arteries in vitro. Cardiovasc Res 24:614–622
Levi R, Hordof A, Edie R, Rosen M (1978) Histamine effects on human atria (abstract). Circulation 58 [Suppl 2]:105
Shah R (1982) Symptomatic bradycardia in association with H2 receptor antagonists. Lancet II:1108
Shimp LA, Smith MA, Wahr DW (1989) Ranitidine induced chest pain. Ann Pharmacother 23:224–226
Top 200 drugs of 1987 (1988) Pharm Times 54:38–46
Vial T, Goubier C, Bergeret A, Cabiera F, Evreux JC, Descotes J (1991) Side effects of ranitidine. Drug Safety 6:94–117
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Nahum, E., Reish, O., Naor, N. et al. Ranitidine-induced bradycardia in a neonate — a first report. Eur J Pediatr 152, 933–934 (1993). https://doi.org/10.1007/BF01957535
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DOI: https://doi.org/10.1007/BF01957535