Skip to main content
SpringerLink
Log in

Evidence to support the hypothesis that ATP is a co-transmitter in rat vas deferens

  • Short Communications
  • Published:
Experientia Aims and scope Submit manuscript

Summary

Application of exogenous ATP or of noradrenaline (NA) produced responses in bisected rat vas deferens which mimicked the biphasic responses to nerve stimulation, and these actions were modified by nifedipine and verapamil in a manner similar to the modification of the 2 phases of the responses of the vas to nerve stimulation. It is proposed that sufficient evidence now exists to support the hypothesis that in this tissue, ATP is released along with NA from the motor nerves and that ATP may indeed be a co-transmitter.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Sjostrand, N. O., Acta physiol. scand., suppl.65 (1962) 257.

    Google Scholar 

  2. Hukovic, S., Br. J. Pharmac.16 (1961) 188.

    CAS  Google Scholar 

  3. Hughes, J., Br. J. Pharmac.49 (1973) 706.

    Article  CAS  Google Scholar 

  4. Burnstock, G., Neuroscience1 (1976) 239.

    Article  CAS  PubMed  Google Scholar 

  5. Burnstock, G., Br. med. J.35 (1979) 255.

    CAS  Google Scholar 

  6. McGrath, J. C., J. Physiol., Lond.283 (1978) 23.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. French, A. M., and Scott, N. C., Br. J. Pharmac.74 (1981) 182P.

    Google Scholar 

  8. French, A. M., and Scott, N. C., Br. J. Pharmac.73 (1981) 321.

    Article  CAS  Google Scholar 

  9. Blakely, A. G. H., Brown, D. A., Cunnane, T. C., French, A. M., McGrath, J. C., and Scott, N. C., Nature,294 (1981) 759.

    Article  Google Scholar 

  10. Eccles, J. C., The Physiology of synapses. Springer, Berlin 1964.

    Book  Google Scholar 

  11. Stjarne, L., and Lishajko, F., J. Neurochem.13 (1966) 1213.

    Article  CAS  PubMed  Google Scholar 

  12. Aberer, A., Stitzel, R., Winkler, H., and Huber, E., J. Neurochem.33 (1979) 797.

    Article  CAS  PubMed  Google Scholar 

  13. Euler, U. S. von, Lishajko, T., and Stjarne, L., Acta physiol. scand.59 (1963) 495.

    Article  Google Scholar 

  14. Fedan, J. S., Hogaboom, G. K., O'Donnell, J. P., Colby, J., and Westfall, D. P., Eur. J. Pharmac.69 (1981) 41.

    Article  CAS  Google Scholar 

  15. Booth, F. J., Connell, J. R., Docherty, J. R., and McGrath, J. C., J. Physiol.280 (1978) 19P.

  16. Smith, A. D., Pharmac. Rev.24 (1972) 435.

    CAS  Google Scholar 

  17. Geffen, L. B., and Livett, B. G., Physiol. Rev.51 (1971) 98.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pharmacology Section, Department of Pharmacy, Heriot-Watt University, EH1 2HJ, Edinburgh, Scotland

    A. M. French & N. C. Scott

Authors
  1. A. M. French
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. C. Scott
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

French, A.M., Scott, N.C. Evidence to support the hypothesis that ATP is a co-transmitter in rat vas deferens. Experientia 39, 264–266 (1983). https://doi.org/10.1007/BF01955295

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01955295

Keywords

Search

Navigation