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The effect of thiazol-4-ylmethoxyamine, a histidine decarboxylase inhibitor, on the development of morphine tolerance and physical dependance in mice

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Summary

A new histidine decarboxylase inhibitor, thiazol-4-ylmethoxyamine (TMA), injected into mice in a dose of 100 mg/kg i.p. 48 h before the implantation of a morphine-containing pellet, inhibited the development of morphine tolerance and physical dependence.

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Author notes

  1. Koon-Sea Hui

    Present address: New York State Research Institute for Neurochemistry and Drug Addiction, 10035, Ward's Island, New York, USA

Authors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine, University of Hong Kong, 5 Sassoon Road, Hong Kong

    Koon-Sea Hui

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  1. Koon-Sea Hui
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Additional information

I thank the World Health Foundation (Hong Kong) for a grant in aid of this research.

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Hui, KS. The effect of thiazol-4-ylmethoxyamine, a histidine decarboxylase inhibitor, on the development of morphine tolerance and physical dependance in mice. Experientia 32, 1313–1315 (1976). https://doi.org/10.1007/BF01953112

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  • DOI: https://doi.org/10.1007/BF01953112

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