Skip to main content
Log in

Chronic active hepatitis in mice induced by 3-hydroxy-4-pyrone

  • Short Communications
  • Published:
Experientia Aims and scope Submit manuscript

Summary

Chronic active hepatitis was selectively induced in mice by the feeding of a diet containing 3-hydroxy-4-pyrone (0.5% by weight) for periods of 6 weeks and longer. This model should be of particular value in elucidating the pathogenesis of drug-induced forms of chronic active hepatitis. Maltol (3-hydroxy-2-methyl-4-pyrone) did not produce any liver lesion.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literatur

  1. Sherlock, S., Diseases of the liver and biliary system, 6th edn, p. 270. Blackwell, London 1981.

    Google Scholar 

  2. Bianchi, L., De Groote, J., Desmet, V.J., Gedigk, P., Korb, G., Popper, H., Poulsen, H., Scheuer, P.J., Schmid, M., Thaler, H., and Wepler, W., Lancet2 (1977) 914.

    Google Scholar 

  3. Borchardt, R.T., J. med. Chem.16 (1973) 581.

    Article  CAS  PubMed  Google Scholar 

  4. Lee, C.P., Hegarty, M.P., and Christie, G.S., Chem.-biol. Interact.27 (1979) 17.

    Article  CAS  PubMed  Google Scholar 

  5. Hegarty, M.P., Lee, C.P., Christie, G.S., Court, R.D., and Haydock, K.P., Aust. J. biol. Sci.32 (1979) 27.

    Article  CAS  PubMed  Google Scholar 

  6. Lindberg, J., Lindholm, A., and Iwarson, S., Lancet1 (1977) 67.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

Acknowledgment. This research was supported in part by a grant from the Sir A.E. Rowden White Bequest to the Department of Pathology, University of Melbourne.

To whom correspondance and requests for reprints should be addressed.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bhathal, P.S., Ho, S.L., Hegarty, M.P. et al. Chronic active hepatitis in mice induced by 3-hydroxy-4-pyrone. Experientia 40, 894–896 (1984). https://doi.org/10.1007/BF01952014

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01952014

Keywords

Navigation