Summary
During pregnancy the synthesis of cholesterol and the activity of 3-hydroxy 3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase fell markedly before parturition; HMGCoA synthase activity was low during pregnancy and fell again immediately before delivery while acetoacetyl-CoA-thiolase was always low and constant.
References
Knopp, R.H., Saudek, C.D., Arky, R.A., and O'Sullivan, J.B., Endocrinology92 (1973) 984.
Scow, R.O., Chernick, S.S., and Brinley, M.S., Am. J. Physiol.206 (1964) 796.
Jones, C.T., Biochem. J.156 (1976) 357.
Jones, C.T., and Firmin, W., Biochem. J.154 (1976) 159.
Lorenzo, M., Caldés, T., Benito, M., and Medina, J.M., Biochem. J.198 (1981) 425.
Philipp, B.M., and Shapiro, D.J., J. Lipid Res.6 (1979) 428.
Lowry, O.H., Rosebrough, N.J., Farr, A.L., and Randall, R.H., J. biol. Chem.193 (1951) 265.
Morrison, W.R., Analyt. Biochem.7 (1964) 218.
Bruscalupi, G., Curatola, G., Lenaz, G., Leoni, S., Mangiantini, M.T., Mazzanti, L., Spagnuolo, S. and Trentalance, A., Biochim. biophys. Acta597 (1980) 263.
Roulston, D.L., Miller, L.R., and Schroepfer, G.J., J. biol. Chem.255 (1980) 4706.
Gould, R.G., and Swyryd, E.A., J. Lipid Res.7 (1966) 698.
Feingold, K.R., Wiley, M.H., Mac Roe, G., and Siperstein, M.D., Metabolism29 (1980) 885.
Lorenzo, M., Benito, M., and Medina, J.M., Trans. biochem. Soc.10 (1982) 396.
Brown, N.S., and Goldstein, J.L., J. Lipid Res.21 (1980) 505.
Ingebritsen, T.S., Geelen, M.J.H., Parker, R.A., Evenson, K.J., and Gibson, D.M., J. biol. Chem.254 (1979) 9986.
Ramachandran, C.R., Grey, S.L., and Melnykovych, G., Archs Biochem. Biophys.189 (1978) 205.
Carlson, S.E., Mitchell, A.D., Carter, M.L., and Godfarb, S., Biochim. biophys. Acta663 (1980) 154.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Leoni, S., Spagnuolo, S., Conti Devirgiliis, L. et al. Cholesterol synthesis and related enzymes in rat liver during pregnancy. Experientia 40, 703–704 (1984). https://doi.org/10.1007/BF01949732
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01949732