Summary
In a rat model of severe hypotension and respiratory depression induced by step-wise bleeding, protoveratrines cause a prompt and sustained improvement of cardiovascular and respiratory functions, both in anesthetized and in conscious animals, seemingly through a magnification of the reflex response originated by the chemoreceptors of aortic and carotid bodies. The restoration of cardiovascular function is attributable to an increase both in total peripheral resistance and cardiac output. The finding could provide the basis for a new approach to the first-aid management of massive blood losses.
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References
Benforado, J. M., in: Physiological Pharmacology, vol. IV, The Nervous System, pp. 331–398. Eds W. S. Root and F. G. Hofmann Academic Press, New York 1967.
Krayer, O., and Meilman, E., in: Handbook of Experimental Pharmacology, vol. XXXIX, Antihypertensive Agents, pp. 547–570. Ed. F. Gross, Springer-Verlag, Berlin 1977.
Eyzaguirre, C., Fitzgerald, R. S., Lahiri, S., and Zapata, P., in: Handbook of Physiology, Section 2, vol. III, The Cardiovascular System-Peripheral Circulation and Organ Blood Flow, pp. 557–621. Eds J. T. Shepherd, F. M. Abboud and S. R. Geiger. American Physiological Society, Bethesda 1983.
Landgren, S., and Niel, E., Acta physiol. scand.23 (1951) 158.
Eyzaguirre, C., and Lewin, J., J. Physiol.159 (1961) 222.
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Bertolini, A., Ferrari, W., Guarini, S. et al. Circulatory and respiratory consequences of massive hemorrhage are reversed by protoveratrines. Experientia 46, 704–708 (1990). https://doi.org/10.1007/BF01939940
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DOI: https://doi.org/10.1007/BF01939940