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Sensitivity of the developing chick myocardium to the positive inotropic effects of calcium and isoproterenol

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Summary

The present results show that the sensitivity of the chick myocardium to the positive motropic effect of Ca++ decreases during development and that the Ca++ concentration of the physiological solution used must be lowered below ‘normal’ to study the effects of positive inotropic agents in preparations from younger embryos. Isoproterenol elicits positive inotropic responses in 7–9-day embryonic ventricle and in newborn chick atria; however, the 4-day embryonic myocardium is unresponsive to isoproterenol.

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Author notes

  1. M. Marlene Hosey

    Present address: Department of Biochemistry, University of Illinois at the Medical Center, 835 South Wolcott, 60612, Chicago, Illinois, USA

Authors and Affiliations

  1. Department of Pharmacology, University of Illinois at the Medical Center, 901 South Wolcott Avenue, P. O. Box 6998, 60612, Chicago, Illinois, USA

    M. Marlene Hosey & R. D. Green

Authors
  1. M. Marlene Hosey
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  2. R. D. Green
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Additional information

This work was supported by Grant No. HL-15995 from the National Heart Institute (USPHS).

The authors would like to thank Dr.F. E. Shideman for the isolated tissue baths used in these experiments.

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Marlene Hosey, M., Green, R.D. Sensitivity of the developing chick myocardium to the positive inotropic effects of calcium and isoproterenol. Experientia 33, 43–45 (1977). https://doi.org/10.1007/BF01936744

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  • DOI: https://doi.org/10.1007/BF01936744

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