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Die Hemmung von Enzymen der Inneren Mitochondrienmembran durch Benzbromaron

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Summary

The uricosuric drug benzbromarone inhibits a number of membrane-bound mitochondrial enzymes. A strong inhibition of succinate dehydrogenase, α-glycerophosphate dehydrogenase and pyridinnucleotide transhydrogenase was found (approximately 28, 48, 45 μM benzbromarone for 50% inhibition respectively). Some possible consequences of these results for the lipid metabolism in patients during benzbromarone are discussed.

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Authors and Affiliations

  1. Medizinisch-Chemisches Institut der Universität Wien, Währingerstrasse 10, A-1090, Wien, Österreich

    R. Kramar & M. M. Müller

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  1. R. Kramar
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  2. M. M. Müller
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Kramar, R., Müller, M.M. Die Hemmung von Enzymen der Inneren Mitochondrienmembran durch Benzbromaron. Experientia 29, 391–392 (1973). https://doi.org/10.1007/BF01926738

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