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Quercetin inhibits hexose transport in a human diploid fibroblast

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Summary

The flavonol quercetin, a phloretin analog, inhibits transport of 2-deoxyglucose and 3-O-methylglucose in a cultured human diploid fibroblast. This inhibition is related to transport itself and not to the reported effects of flavonoids on membrane-bound ATPases. From concentration-inhibition curves at several pH's we conclude that uncharged (acid) quercetin (pK=7.65) is the inhibitory form of the molecule (K I =10μm). Quercetin, unlike phloretin, is rapidly degraded in 0.1n NaOH; the degradation products are weakly inhibitory to hexose transport.

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Author notes

  1. Donald W. Salter

    Present address: Department of Microbiology, University of Illinois, 61801, Urbana, Illinois

Authors and Affiliations

  1. University of Tennessee-Oak Ridge Graduate School of Biomedical Sciences, 37830, Oak Ridge, Tennessee

    Donald W. Salter, Susan Custead-Jones & John S. Cook

  2. Biology Division, Oak Ridge National Laboratory, 37830, Oak Ridge, Tennessee

    Donald W. Salter, Susan Custead-Jones & John S. Cook

Authors
  1. Donald W. Salter
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  2. Susan Custead-Jones
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  3. John S. Cook
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Salter, D.W., Custead-Jones, S. & Cook, J.S. Quercetin inhibits hexose transport in a human diploid fibroblast. J. Membrain Biol. 40, 67–76 (1978). https://doi.org/10.1007/BF01909739

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  • DOI: https://doi.org/10.1007/BF01909739

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