Summary
In cultivation of the thymus of newly born mice in a diffusion chamber in vivo there occurs quick disappearance of lymphocytes and proliferation of epithelial membranes with focal structures after the type of Hassal's corpuscles.
Upon repeated injection of lymphocytes from various sources into a chamber containing such epithelial stroma their differentiation is maintained, and there are formed lymphoid accumulations which are often associated with Hassal's bodylike structures. The thymus epithelium in the chamber, however, does not influence the differentiation of bone marrow cells.
In cultivation of the spleen in a diffusion chamber the myeloid cells are retained during the first ten days as foci of 3–5 cells lying on one reticular cell.
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Luriya, E.A., Snegireva, A.E. Effect of the epithelial stroma of the thymus on differentiation of lymphocytes. Bull Exp Biol Med 61, 579–582 (1966). https://doi.org/10.1007/BF01892460
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DOI: https://doi.org/10.1007/BF01892460