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Influence of histamine and antidiuretic hormone on diuresis and renal excretion of the enzyme hyaluronidase

  • Physiology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

Experiments on dogs with ureters exposed by Pavlov's method were used to study the influence of a single intravenous injection of histamine and antidiuretic hormone (pituitrin) on the water excreting function of the kidney and excretion of hyaluronidase enzyme with urine. It was established that injection of histamine as well as of antidiuretic hormone caused a reduction in diuresis with a simultaneous appearance of hyaluronidase enzyme in the urine; at the same time, as the enzyme concentration in the urine became greater the more considerable was the reduction of diuresis.

The results of the investigations give ground to suppose that the antidiuretic effect of histamine on the kidney is partly due to the presence of hyaluronidase enzyme.

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Authors and Affiliations

  1. Laboratory of the Physiology of Excretion A. A. Bogomolets Institute of Physiology, Academy of Sciences of the UkrSSR, Kiev

    M. S. Yaremenko & N. P. Kushch

Authors
  1. M. S. Yaremenko
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  2. N. P. Kushch
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Yaremenko, M.S., Kushch, N.P. Influence of histamine and antidiuretic hormone on diuresis and renal excretion of the enzyme hyaluronidase. Bull Exp Biol Med 61, 484–487 (1966). https://doi.org/10.1007/BF01892433

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  • DOI: https://doi.org/10.1007/BF01892433

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