Summary
The study describes an attempt to determine the minimal sleep infusion rate for the intravenous anaesthetic, methohexitone using EEG power spectral edge (PSE) as an index of anaesthetic depth. PSE was found to remain stable during a continuous infusion at declining rates, with decreasing plasma concentration. We were unable to define a sleep infusion rate using PSE as an index of anaesthetic depth. PSE was found to be unsuitable for monitoring anaesthetic depth.
Similar content being viewed by others
References
Eger I, Saidman L, Brandstater B: Minimum alveolar concentrations: a standard of anaesthetic potency. Anesthesiology 26: 756, 1965.
Merkel G, Eger I: A comparative study of halothane and halopropane anaesthesia including method for determining equipotency. Anesthesiology 24: 346, 1963.
Prys-Roberts C: Practical and pharmacological implications of continuous intravenous anaesthesia. Acta Anesth Belg 31: 225–230, 1980.
Sear JW, Prys-Roberts C: Dose related haemodynamic effects of continuous infusion of Althesin in man. Br J Anaesth 51: 867–873, 1979.
Rampil IJ, Sasse FJ, Smith NT, Hoff BH, Flemming DC: Spectral edge frequency — a new correlate of anesthetic depth. ASA Abstracts, Anesthesiology 53, No. 3, Sept. 1980.
Hudson R, Stanski D, Saidman L, Meathe E: A model for studying depth of anaesthesia and acute tolerance to thiopental. Anesthesiology 59: 301–308, 1983.
Scott JC, Ponganis KV, Stanski DR: EEG quantification of narcotic effect: The comparative pharmacodynamics of fentanyl and alfentanil. Anesthesiology 62: 234–241, 1985.
Hudson R, Stanski D, Burch P: Comparative pharmacokinetics of methohexital and thiopentone. Anesthesiology 56: 263–8, 1982.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Withington, P.S., Morton, J., Arnold, R. et al. Assessment of power spectral edge for monitoring depth of anaesthesia using low methohexitone infusion. International Journal of Clinical Monitoring and Computing 3, 117–122 (1986). https://doi.org/10.1007/BF01880764
Issue Date:
DOI: https://doi.org/10.1007/BF01880764