Summary
By using those cases of adenomatosis coli (AC) collected by Center for Polyposis Registration in Japan, an attempt was made for estimating frequency of the disease. Although year of diagnosis could be traced back to as early as 1954, the observed period was restricted to 1961 through 1975 because of their relatively constant performance for registration. All Japan was divided into prefectures and Tokyo Metropolitan Area alone was further subdivided into special wards (ku). Cumulative incidence rate through all ages was proposed for an estimate of the frequency (f) of the disease at birth. Based on the observation that the secondary/proband ratio was roughly 1.0 and on the assumption that those districts with largest values of incidence rate as the most likely estimator of the frequency, f was estimated to be 5.74×10−5. This estimate is agreeable with those obtained by other authors with different materials and methods.
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This work was partly supported by a Grant-in-Aid of Scientific Research Results, No. 501030 from the Ministry of Education, Science and Culture of Japan.
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Murata, M., Utsunomiya, J., Iwama, T. et al. Frequency of adenomatosis coli in Japan. Jap J Human Genet 26, 19–30 (1981). https://doi.org/10.1007/BF01871370
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DOI: https://doi.org/10.1007/BF01871370
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