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Prospects of immunotherapy for rheumatoid arthritis

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Abstract

The main challenge in the development of new modalities for the treatment of rheumatoid arthritis is to enhance the specificity while reducing the adverse side-effects of therapeutics. Biotechnology provides a variety of reagents, such as monoclonal antibodies, recombinant cytokines, cytokine antagonists, and small peptides, with the potential to interfere with selected stages of the disease process in a highly specific manner. In addition, several new therapeutic approaches have emerged as a result of extensive research with animal models of disease, including T-cell vaccination and bone marrow transplantation. This article discusses current insights into the pathogenesis of rheumatic diseases, focusing on rheumatoid arthritis. A number of new therapeutic modalities for rheumatoid arthritis, in particular those acting on the immune system, are discussed. Because it is not possible to provide a complete overview of all the developments in the field in limited space, a selection of strategies and modalities which are representative of the broad variety of immunotherapeutic approaches currently used are highlighted.

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  1. Department of Immunobiology, Biomedical Primate Research Centre, P.O. Box 3306, 2280, GH Rijswijk, The Netherlands

    Bert A. 't Hart

  2. Department of Immuno-Haematology, University Hospital, Utrecht, The Netherlands

    Henny G. Otten

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't Hart, B.A., Otten, H.G. Prospects of immunotherapy for rheumatoid arthritis. Pharm World Sci 17, 178–185 (1995). https://doi.org/10.1007/BF01870608

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