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Radon exposure in residences and lung cancer among women: combined analysis of three studies

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Abstract

Lung cancer risk in relation to indoor radon was examined in three case-control studies in Stockholm (Sweden), New Jersey (United States), and Shenyang (People's Republic of China). Year-long measurements of radon gas were made in current and past homes of 966 women who developed lung cancer and of 1,158 control women, included in the combined analysis. Nearly 14 percent of the participants were estimated to have a time-weighted, mean, radon concentration in their homes of more than 4 pCi/l (150 Bq/m3) during the period from five to 35 years prior to the date of lung cancer diagnosis (or comparable date for controls). There was a tendency for risk to increase with increasing levels of randon in NJ and Stockholm, but the trends for individual studies and overall were not statistically significant. The estimates of the excess relative risk for indoor exposure per pCi/l were 0.18 (95 percent [CI]=−0.04–0.70) in NJ, 0.06 (CI=−0.05–0.34) in Stockholm, and −0.02 (CI=−∞–0.03) for Shenyang; these estimates did not differ significantly from each other. The overall excess RR per pCi/l was 0.00 (CI=−0.05–0.07); the confidence limits were sufficiently broad, however, that the overall estimate was still compatible with extrapolations of risks from miners. Cigarette smoking was the predominant cause of lung cancer with the RR significantly elevated in all studies. Within smoking categories, the trend in risk with increasing mean radon concentration was inconsistent. Analyses of data from several studies are complicated by the possibility that there may exist important differences in study bases which might affect results, and which may be controlled only partially through adjustment procedures. Future efforts to combine various residential studies will need to be attentive to the intrinsic limitations of studies to detect low levels of risk as well as the unique uncertainties associated with estimating, accurately, cumulative exposure to indoor radon.

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References

  1. National Research Council, Committee on Biological Effects of Ionizing Radiation.Health Risks of Radon and Other Internally Deposited Alpha-emitters, BEIR IV. Washington DC, USA: National Academy Press, 1988.

    Google Scholar 

  2. Lubin JH, Boice JD Jr. Estimating Rn-induced lung cancer in the United States.Health Phys 1989;57: 417–27.

    PubMed  Google Scholar 

  3. Puskin JS, Nelson CB. EPA's perspective on risks from residential radon exposure.J Am Air Poll Control Assoc 1989;39: 915–20.

    Google Scholar 

  4. National Research Council, Board on Radiation Effects Research.Comparative Dosimetry of Radon in Mines and Homes. Washington DC, USA: National Academy Press, 1991.

    Google Scholar 

  5. Samet JM, Radon and lung cancer.JNCI 1989;81: 745–57.

    PubMed  Google Scholar 

  6. Samet JM, Stolwijk J, Rose S. Summary: International workshop on residential Rn epidemiology.Health Phys 1991;60: 223–7.

    PubMed  Google Scholar 

  7. Lubin JH, Samet JM, Weinberg C. Design issues in epidemiologic studies of indoor exposure to Rn and risk of lung cancer.Health Phys 1990;59: 807–17.

    PubMed  Google Scholar 

  8. Brenner H, Savitz DA, Jockel KH, Greenland S. Effects of nondifferential misclassification in ecologic studies.Am J Epidemiol 1992;135: 85–95.

    PubMed  Google Scholar 

  9. Blot WJ, Xu ZY, Boice JD Jr et al. Indoor radon and lung cancer in China.JNCI 1990;82: 1025–30.

    PubMed  Google Scholar 

  10. Schoenberg JB, Klotz JB, Wilcox GP, Gil-del-Real MT, Stemhagen A, Mason TJ. Case-control study of residential radon and lung cancer among New Jersey women.Cancer Res 1990;50: 6520–4.

    PubMed  Google Scholar 

  11. Schoenberg JB, Klotz JB, Wilcox HB, Szmaciasz SF. A case-control study of radon and lung cancer in New Jersey women. In: Proceedings, 29th Hanford (WA, USA) Symposium: Indoor Radon and Lung Cancer: Reality or Myth; Part 2, pp. 905–17, 1992.

  12. Pershagen G, Liang Z-H, Hrubec Z, Svensson C, Boice JD Jr. Residential radon exposure and lung cancer in Swedish women.Health Phys 1992;63: 179–86.

    PubMed  Google Scholar 

  13. National Research Council, Committee on the Biological Effects of Ionizing Radiations.The Effects on Populations of Exposure to Low Levels of Ionizing Radiation: 1980. Washington, DC: National Academy Press, 1980.

    Google Scholar 

  14. Toohey RE, Essling MA, Rundo J, Hengde W. Some measurements of the equilibrium factor for222Rn daughters in houses.Health Phys 1987;53: 89–91.

    PubMed  Google Scholar 

  15. Toohey RE, Watson JE Jr. Radon—getting the dosimetry right.J Am Med Assoc 1988;260: 3127–8.

    Google Scholar 

  16. Nero AV, Schwehr MB, Nazaroff WW, Revzan KL. Distribution of airborne radon-222 concentrations in US homes.Science 1986;234: 992–7.

    PubMed  Google Scholar 

  17. White SB, Bergsten JW, Alexander BV, Rodman NF, Phillips JL. Indoor222Rn concentations in a probability sample of 43,000 houses across 30 states.Health Phys 1992;62: 41–50.

    PubMed  Google Scholar 

  18. Swedjemark GA. Radon and its decay products in housing. Estimation of the radon daughter exposure to the Swedish population and methods for evaluation of the uncertainties in annual averages. Doctoral Dissertation, Department of Radiation Physics, University of Stockholm, 1985.

  19. National Radiological Protection Board,The Householders' Guide to Radon (Second Edition). Oxfordshire, UK: Department of the Environment, National Radiological Protection Board, 1990.

    Google Scholar 

  20. United States Environmental Protection Agency.A Citizens' Guide to Radon (Second Edition).The Guide to Protecting Your Family from Radon. Washington DC: US Environmental Protection Agency, 1992; EPA Pub. ANR-464.

    Google Scholar 

  21. Swedish National Board of Health and Welfare.Radon. Recommendations from the National Board of Health and Welfare 1990: 5. Stockholm, Sweden (in Swedish): SNBHW, 1990.

    Google Scholar 

  22. Bierma TJ, Croke KG, Swartzman D. Accuracy and precision of home monitoring and the effectiveness of EPA monitoring guidelines.J Am Air Poll Control Assoc 1989;39: 953–9.

    Google Scholar 

  23. Svensson C, Pershagen G, Hrubec Z. A comparative study on different methods of measuring Rn concentrations in homes.Health Phys 1988;55: 895–902.

    PubMed  Google Scholar 

  24. Svensson C, Pershagen G, Klominek J. Lung cancer in women and type of dwelling in relation to radon exposure.Cancer Res 1989;49: 1861–5.

    PubMed  Google Scholar 

  25. Xu ZY, Blot WJ, Xiao HP, et al. Smoking, air pollution and the high rates of lung cancer in Shenyang, China.JNCI 1989;81: 1800–6.

    PubMed  Google Scholar 

  26. Preston DL, Lubin JH, Pierce DA.EPICURE: Generalized Regression Models for Epidemiologic Data. Seattle, WA: HiroSoft International Corporation, 1990.

    Google Scholar 

  27. Bäverstam U, Swedjemark GA. Where are the errors when we estimate radon exposure in retrospect?Radiat Prot Dos 1991;36: 107–12.

    Google Scholar 

  28. Gao YT, Blot WJ, Zheng W, Fraumeni JF Jr, Hsu CW. Lung cancer and smoking in Shanghai.int J Epidemiol 1988;17: 277–80.

    PubMed  Google Scholar 

  29. Koo LC, Ho JH, Lee N. An analysis of some risk factors for lung cancer in Hong Kong.Int J Cancer 1985;35: 149–55.

    PubMed  Google Scholar 

  30. Lubin JH, Qiao YL, Taylor PR, et al. A quantitative evaluation of the radon and lung cancer association in a case-control study of Chinese tin miners.Cancer Res 1990;50: 174–80.

    PubMed  Google Scholar 

  31. Lubin JH, Li JY, Xuan XZ, et al. Risk of lung cancer among cigarette and pipe smokers in Southern China.Int J Cancer 1992;51: 390–5.

    PubMed  Google Scholar 

  32. Abelson PH: Mineral dusts and radon in uranium mines.Science 1991:254: 777.

    PubMed  Google Scholar 

  33. Amandus HE, Shy C, Wing S, Blair A, Heineman EF. Silicosis and lung cancer in North Carolina dusty trades workers.Am J Ind Med 1991;20: 57–70.

    PubMed  Google Scholar 

  34. International Agency for Research on Cancer.Diesel and Gasoline Exhausts and Some Nitroamines. Lyon, France: International Agency for Research on Cancer, 1989;Monogr Eval Carcinog Risk Chem Man, Vol. 46.

    Google Scholar 

  35. Spiethoff A, Wesch H, Wegener K, Klimisch HJ. The effect of Thorotrast and quartz on the induction of lung tumors in rats.Health Phys 1992;63: 101–10.

    PubMed  Google Scholar 

  36. Hornung RW, Meinhardt TJ. Quantitative risk assessment of lung cancer in the U.S. uranium miners.Health Phys 1987;52: 417–30.

    PubMed  Google Scholar 

  37. Ševc J, Kunz E, Tomasek L, Plack V, Horacck J. Cancer in man after exposure to Rn daughters.Health Phys 1988;54: 27–46.

    PubMed  Google Scholar 

  38. Cross FT. A review of experimental animal radon health effects data. In: Dewev WC, Edington M, Fry RJM, Hall EJ, Whitmore GF, eds.Radiation Research: A Twentieth Century Perspective. San Diego, CA: Academic Press, 1992; 476–81.

    Google Scholar 

  39. Darby SC, Doll R. Radiation and exposure rate (Letter).Nature 1990;344: 824.

    PubMed  Google Scholar 

  40. Brenner DJ, Hall EJ, Randers-Pehrson G, Miller RC. Mechanistic considerations on the dose-rate/IET dependence of oncogenic transformation by ionizing radiation.Radiat Res 1993;133: 365–9.

    PubMed  Google Scholar 

  41. Lagarde F. Statistical aspects of the influence of indoor radon exposure and smoking on the risk of lung cancer. Stockholm: University of Stockholm, 1992;Instit Actuarial Math Math Stat, Report No. B:21.

    Google Scholar 

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Author notes

  1. Zhonghua Liang

    Present address: The Mount Sinai Medical Center, New York, NY, USA

Authors and Affiliations

  1. Epidemiology and Biostatistics Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    Jay H. Lubin,  Zdenek Hrubec,  William J. Blot &  John D. Boice Jr.

  2. Department of Epidemiology, Karolinska Institute, Stockholm, Sweden

    Zhonghua Liang &  Göran Pershagen

  3. New Jersey State Department of Health, Trenton, NJ, USA

    Janet B. Schoenberg &  Judith B. Klotz

  4. Liaoning Public Health and Anti-Epidemic Station, Shenyang, People's Republic of China

    Zhao-Yi Xu

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  1. Jay H. Lubin
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  2. Zhonghua Liang
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  4. Göran Pershagen
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  9. John D. Boice Jr.
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Additional information

The New Jersey study was supported in part by the State of New Jersey and by Contract N01-CP-61031 and Grant R01-CA-37744 from the US National Cancer Institute. The Stockholm study was supported by contracts and grants from the Jubilee Fund of the Swedish National Bank, the Swedish National Institute for Radiation Protection, and the US National Cancer Institute. The Shenyang study was supported by Contract N01-CP-51021 of the US National Cancer Institute.

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Lubin, J.H., Liang, Z., Hrubec, Z. et al. Radon exposure in residences and lung cancer among women: combined analysis of three studies. Cancer Causes Control 5, 114–128 (1994). https://doi.org/10.1007/BF01830257

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  • DOI: https://doi.org/10.1007/BF01830257

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