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The incidence of rubella virus infections in Switzerland after the introduction of the MMR mass vaccination programme

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Abstract

We have collected data on the incidence of rubella in Switzerland from 1987 to 1992 to help evaluating the impact of the measles, mumps and rubella (MMR) mass vaccination programme which started in 1985 in this country. We used detailed informations on samples submitted for diagnostic testing in conjunction with anonymous laboratory notifications to the Swiss Federal Office for Public Health, and data from the Swiss sentinel network of general practitioners to find trends in the incidence of rubella after the introduction of mass vaccination. We observed an unabated seasonal oscillation without decreasing trend during the observation period and were unable to detect a shift in the age distribution of cases. An important proportion of laboratory-confirmed rubella occurred in women of childbearing age. Immigrants from regions with low endemicity of rubella were at increased risk of contracting rubella and transmitting it to their offspring. We conclude, that MMR mass vaccination has not interrupted the circulation of rubella virus in Switzerland, and that improvements in the implementation and surveillance of the MMR vaccination campaign are necessary in order to avoid untoward effects of it.

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References

  1. Anderson RM, Grenfell BT. Quantitative investigations of different vaccination policies for the control of congenital rubella syndrome (CRS) in the United Kingdom. J Hyg Cambr 1986; 96: 305–333.

    Google Scholar 

  2. Anderson RM, May RM. Vaccination against rubella and measles: quantitative investigations of different policies. J Hyg Cambr 1983; 90: 259–325.

    Google Scholar 

  3. Anderson RM, May RM. Immunisation and herd immunity. Lancet 1990; 335: 641–645.

    Google Scholar 

  4. Armitage P, Berry G. Statistical methods in medical research, 2nd ed. Oxford: Blackwell Scientific Publications, 1987.

    Google Scholar 

  5. Assaad F, Ljungars-Esteves K. Rubella: World impact. Rev Infect Dis 1985; 7 (Suppl 1) S29–36.

    Google Scholar 

  6. Bundesamt für Gesundheitswesen. Meldewesen. In: Infektionskrankheiten. Diagnose und Bekämpfung, edited by Bundesamt für Gesundheitswesen. Bern, 1987: 410–433.

  7. Bundesamt für Gesundheitswesen. MMR-Impfkam-pagne, Antworten auf verschiedene Argumente gegen die Impfkampagne. Bull BAG 1989; 42: 558–566.

    Google Scholar 

  8. Bundesamt für Gesundheitswesen. Masern-, Mumps-, Röteln-Durchimpfung bei Schulkindern in der Schweiz 1987–1990. Bull BAG 1991; 19: 278–283.

    Google Scholar 

  9. Bundesamt für Gesundheitswesen. Kleinkinder-impfungen. Eine repr äsentative Erhebung zur Durchimpfung in der Schweiz 1991. Bull BAG 1992; 32: 504–507.

    Google Scholar 

  10. Bundesamt für Statistik. Bevölkerung. In: Statistisches Jahrbuch der Schweiz 1993, edited by Bundesamt für Statistik. Zürich: Verlag Neue Z ürcher Zeitung, 1992: 35–78.

    Google Scholar 

  11. Centers for Disease Control. Rubella and congenital rubella syndrome — United States, 1984–1985. Mort Morb Weekly Rep 1986; 35: 129–135.

    Google Scholar 

  12. Centers for Disease Control. Rubella and congenital rubella syndrome — United States, 1985–1988. Mort Morb Weekly Rep 1989; 38: 173–178.

    Google Scholar 

  13. Centers for DiseaseControl. Increase in rubella and congenital rubella syndrome — United States, 1988–1990. Mort Morb Weekly Rep 1991; 40: 93–99.

    Google Scholar 

  14. Centers for Disease Control. Update: Influenza activity — United States, 1991–1992 season. Mort Morb Weekly Rep 1992; 41: 63–65.

    Google Scholar 

  15. Centers for Disease Control. Congenital rubella syndrome among the Amish — Pennsylvania, 1991–1992. Mort Morb Weekly Rep 1992; 41: 468–476.

    Google Scholar 

  16. Cochi SL, Edmonds LE, Dyer K, Greaves WL, Marks JS, Rovira EZ, Preblud SR, Orenstein WA. Congenital rubella syndrome in the United States, 1970–1985: On the verge of elimination. Am J Epidemiol 1989; 129: 349–361.

    Google Scholar 

  17. Cusi MG, Rossolini GM, Valensin PE, Cellesi C, Zanchi A. Serological evidence of reinfection among vaccinees during rubella outbreak. Lancet 1990; 336: 1071.

    Google Scholar 

  18. De la Mata I, De Wals P, Dolk H, et al. Incidence of congenital rubella syndrome in 19 regions of Europe in 1980–1986. Eur J Epidemiol 1989; 5: 106–109.

    Google Scholar 

  19. Gassner M, Zimmermann HP. Röteln. In: Bollag U, Cloëtta J, Gassner M, Kammerlander R, Matter HC, Rüetschi B, Wick A, Zimmermann HP (eds), Sentinella 1991/92. Bundesamt für Gesundheitswesen, Bern Liebefeld, 1993: 60–63.

    Google Scholar 

  20. Gomwalk NE, Ahmad AA. Prevalence of rubella antibodies on the African Continent. Rev Infect Dis 1989; 11: 116–121.

    Google Scholar 

  21. Grenfell BT, Anderson RM. The estimation of age-related rates of infection from case notifications and serological data. J Hyg Cambr 1985; 95: 419–436.

    Google Scholar 

  22. Gurtner F. The sentinel network of family practitioners in Switzerland: Its aims, its methods and its use for public health. Thesis. London, 1990.

  23. Just M. Der neue schweizerische Impfplan. Ther Umschau 1986; 43: 565–571.

    Google Scholar 

  24. Just M, Berger R, Lüscher D, Raupp E, Ritzel G. Elimination von Masern, Röteln und Mumps. Schweiz Ärztezeitung 1987; 68: 515–518.

    Google Scholar 

  25. Miller CL. Rubella in the developing world. Epidem Inf 1991; 107: 63–68.

    Google Scholar 

  26. Miller E. Rubella in the United Kingdom. Epidem Inf 1991; 107: 31–42.

    Google Scholar 

  27. Miller E, Nicoll A, Rousseau SA, Sequeira PJL, Hambling MH, Smithells RW, Holzel H. Congenital rubella in babies of south Asian women in England and Wales: An excess and its causes. Br Med J 1987; 294: 737–739.

    Google Scholar 

  28. Miller E, Waight PA, Vurdien JE, Jones G, Tookey PA, Peckham CS. Rubella surveillance to december 1992: Second joint report from the PHLS and National Congenital Rubella Surveillance Program. CDR Review, 1993; 3: R35-R40.

    Google Scholar 

  29. Mingle JAA. Frequency of rubella antibodies in the population of some tropical African countries. Rev Infect Dis 1985; 7 (Suppl) 1: 68–71.

    Google Scholar 

  30. Ng T, Farley JD, Syrja L, Middleton PJ, Nicoll J, Millar J. Rubella activity, 1989 — British Columbia. Can Dis Weekly Rep 1989; 15: 97–99.

    Google Scholar 

  31. Nokes DJ, Anderson RM. The use of mathematical models in the epidemiological study of infectious diseases and the design of mass immunization programmes. Epidem Inf 1988; 101: 1–20.

    Google Scholar 

  32. Nokes DJ. Anderson RM. Mathematical models of infectious agent transmission and the impact of mass vaccination. Rev Med Microbiol, 1992; 3: 187–195.

    Google Scholar 

  33. Nokes DJ, Anderson RM, Anderson MJ. Rubella epidemiology in South East England. J Hyg Cambr 1986; 96: 291–304.

    Google Scholar 

  34. Peltola H, Kurki T, Virtanen M, Nissinen M, Karanko V, Hukkanen V, Penttinen K, Heinonen OP. Rapid effect on endemic measles, mumps, and rubella of nationwide vaccination programme in Finland. Lancet 1986 (i): 137–139.

  35. PHLS Communicable Disease Surveillance Center. The resurgence of rubella? Comm Dis Rep 1993; 3: 39.

    Google Scholar 

  36. Schmidt NJ, Lennette EH, Woodie JD, Ho HH. Identification of rubella virus isolates by immunofluorescent staining, and a comparison of the sensitivity of three cell culture systems for the recovery of virus. J Lab Clin Med 1966; 68: 502–509.

    Google Scholar 

  37. Somaini B. Ziele des Masern/Mumps/Röteln-Impfprogramms. Bull BAG 1988; 3: 31–36.

    Google Scholar 

  38. Ukkonen P, Von Bonsdorff CH. Rubella immunity and morbidity: Effects of vaccination in Finland. Scand J Infect Dis 1988; 20: 255–259.

    Google Scholar 

  39. Upfold LJ. Changes in the significance of maternal rubella as a factor in childhood deafness - 1954 to 1982. Med J Aust 1984; 140: 641–644.

    Google Scholar 

  40. World Health Organisation. Expanded Programme on Immunisation: A report from the programme on Communicable Diseases. Copenhagen: WHO, 1989.

    Google Scholar 

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Authors and Affiliations

  1. Institute for Medical Microbiology, University of Berne, Friedbuhlstrasse 51, CH-3010, Berne, Switzerland

    Lukas Matter, Frank Bally, Daniel Germann & Kurt Schopfer

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  1. Lukas Matter
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  2. Frank Bally
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  3. Daniel Germann
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  4. Kurt Schopfer
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Matter, L., Bally, F., Germann, D. et al. The incidence of rubella virus infections in Switzerland after the introduction of the MMR mass vaccination programme. Eur J Epidemiol 11, 305–310 (1995). https://doi.org/10.1007/BF01719435

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