Skip to main content
SpringerLink
Log in

Modulation of hepatic cytochrome P-450 and DT-diaphorase by oral and sub-cutaneous administration of the pro-oxidant fungicide dichlone (2,3-dichloro-1,4-naphthoquinone)

  • Published:
Bulletin of Environmental Contamination and Toxicology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Anders MW (1971) Enhancement and inhibition of drug metabolism. Ann Rev Pharmacol 11:37–56

    PubMed  Google Scholar 

  • Bachur NR, Gordon SL, Gee MV, Kon H (1979) NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals. Proc Natl Acad Sci 76(2):954–957

    PubMed  Google Scholar 

  • Burns GW (1972) The science of genetics. The Macmillin Comp, New York, New York Campbell CT, Hayes JR (1974) Role of Nutrition in the Drug-Metabolizing Enzyme System Pharmacol Rev 26(3):171

    Google Scholar 

  • Ernster L (1967) DT-diaphorase. Methods in Enzymology 56 (Vol10):309–317

    Google Scholar 

  • Ernster L, Lind C (1974) A possible relationship between DT-diaphorase and the aryl hydrocarbon hydroxylase system. Biochem Biophys Res Com 56(2):392–399

    PubMed  Google Scholar 

  • Gang H, Lieber CS, Rubin E (1972) Aniline hydroxylase microassay suitable for needle biopsy specimens: Effects of phosphate and pyrophosphate on aniline hydroxylase. J Pharamcol Exp Ther 183:218

    Google Scholar 

  • Hojeberg B, Blomberg K, Stenberg S, Lind C (1981) Biospeciflc Adsorption of Hepatic DT-Diaphorase on Immobilized Dicoumarol. Arch Biochem Biophys 207(1):205–216

    PubMed  Google Scholar 

  • Horst WP, Felix EL (1943) CNQ: a potent organic fungicide. Indust Eng Chem 35:1255

    Google Scholar 

  • Lau AYH (1971) Liver microsomes and drug metabolizing enzyme system: functional components and their properties. Fed Proc 35(3):2460

    Google Scholar 

  • Lind C, Hochstein P, Ernster L (1982) DT-diaphorase as a quinone reductase: a cellular control device against semiquinone and Superoxide radical formation. Arch Biochem Biophys 276(1):178–185

    Google Scholar 

  • Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) J Biol Chem 193, 265

    PubMed  Google Scholar 

  • Omura T, Sato R (1978) Isolation of Cytochromes P-450 and P-420 Methods in Enzymology 52(Part C):556–561

    Google Scholar 

  • Pritsos CA, Jensen JC, Pisani D, Pardini RS (1982) Involvement of Superoxide in the interaction of 2,3-dichloro-1,4-naphthoquinone with mitochondrial membranes. Arch Biochem Biophys 217:98

    PubMed  Google Scholar 

  • Pritsos CA, Pisani, DE, Pardini RS (1983) Inhibition of Glutathione Reductase and Peroxidase activity by 2,3-dichlorol,4-napthoquinone. Fed Proc 42:2109

    Google Scholar 

  • Pritsos CA, Pardini RS (1984) A redox-cycling mechanism of action for 2,3-dichloro-1,4-naphthoquinone with mitochondrial membranes and the role of sulfhydryl groups. Biochem Pharamacol 33:3791

    Google Scholar 

  • Pritsos CA, Pisani DE, Pardini RS (1985) Inhibition of liver glycolysis in rats by dietary dichlone (2,3-dichloro-1,4-naph-thoquinone). Bull Environ Contam Toxicol 35:23

    PubMed  Google Scholar 

  • Pritsos CA, Aaronson LM, Pardini RS (1986) Metabolic consequences of dietary 2,3-dichloro-1,4-naphthoquinone (CNQ) In the rat Alteration in the Anti-Oxidant Enzyme Activities. Biochem Pharmacol 35:1131

    PubMed  Google Scholar 

  • Sax NI (1984) Dangerous Properties of Industrial Materials (9th ed). Van Nostrand Reinhold Co, New York, New York

    Google Scholar 

  • Sell JL, Davison KL (1973) Changes in the activities of hepatic microsomal enzymes cause by DDT and dieldrin. Fed Proc 32(9):2003

    PubMed  Google Scholar 

  • Sharvell EG (1961) The Nature and Uses of Modern Fungicides Minneapolis. Burgess Publishing Co, MN

    Google Scholar 

  • Van der Hoeven TA, Coon MJ (1974) Preparation and properties of partially purified cytochrome P-450 and nicotinamide adenine dinucleotlde phosphate-cytochrome P-450 reductase from rabbit liver microsomes. J Biol Chem 249:6302

    PubMed  Google Scholar 

  • Windholz M (ed) (1976) The Merck Index (9th ed). Merck and Co, Rahway, New Jersey

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, University of Nevada-Reno, 89557-0014, Reno, Nevada

    Andrew J. Elliott & Ronald S. Pardini

Authors
  1. Andrew J. Elliott
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ronald S. Pardini
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Elliott, A.J., Pardini, R.S. Modulation of hepatic cytochrome P-450 and DT-diaphorase by oral and sub-cutaneous administration of the pro-oxidant fungicide dichlone (2,3-dichloro-1,4-naphthoquinone). Bull. Environ. Contam. Toxicol. 41, 164–171 (1988). https://doi.org/10.1007/BF01705426

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01705426

Keywords

Search

Navigation