Die antibaktierielle Wirksamkeit von Cefaclor bei Ampicillin-, Tetracyclin- und Co-Trimoxazol-resistenten Keimen

Zusammenfassung

Die antibakterielle Aktivität des neuen Oralcephalosporins Cefaclor wurde an 623 frischen Isolaten untersucht. Gute Wirksamkeit konnte beiEscherichia coli, Proteus mirabilis undKlebsiella festgestellt werden. Nahezu alle Stämme, die Ampicillin-, Tetracyclin- und Co-Trimoxazol-empfindlich waren, konnten auch mit Cefaclor gehemmt werden. Die gegen diese drei Präparate resistenten Isolate waren zum Teil noch Cefaclor-empfindlich: alle von zehn Co-Trimoxazol-resistentenP. mirabilis-Stämmen, 54% der Ampicillin-, Tetracyclin- und Co-Trimoxazol-resistentenE. coli-Isolate und 18% der Tetracyclin-und Co-Trimoxazol-resistenten Klebsiellen.

Summary

The antibacterial activity of the new oral cephalosporin cefaclor was investigated using 623 freshly isolated bacterial strains. A high degree of efficacy of cefaclor was noticed againstEscherichia coli, Proteus mirabilis andKlebsiella. Nearly all strains which were sensitive to ampicillin, tetracycline and co-trimoxazole were also inhibited by cefaclor. Some of the strains resistant to the three above-mentioned antibiotics were also sensitive to cefaclor as follows: all of tenP. mirabilis strains resistant to co-trimoxazole, 54% of theE. coli strains resistant to ampicillin, tetracycline and co-trimoxazole, and 18% of theKlebsiella strains resistant to tetracycline and co-trimoxazole.