Summary
We studied the behaviour of 56 clinical isolates ofPseudomonas aeruginosa strains against the following beta-lactam antibiotics: cefotaxime, cefoperazone, cefsulodin, lamoxactam, Ro 13-9904, azlocillin, mezlocillin and ticarcillin. Twenty-six strains were resistant to gentamicin and 30 to gentamicin and/or carbenicillin. The MICs were measured by the serial dilution test on solid agar. Cefsulodin was the most active cephalosporin against carbenicillin-resistant strains (MIC ≥ 128 mg/l); it inhibited 56.6% of these strains at a concentration of 8 mg/l. Azlocillin was the most active penicillin, inhibiting 79.96% of the same strains at a concentration of 64 mg/l. Cefsulodin was the most active cephalosporin against the gentamicin-resistant group ofPseudomonas aeruginosa strains (MIC ≥ 8 mg/l) which were sensitive to carbenicillin (MIC ≤ 64 mg/l). It inhibited 100% of the strains at a concentration of 4 mg/l. All of the penicillins studied inhibited all of the strains in this group. The required concentrations were the following: 16 mg/l for azlocillin, 32 mg/l for mezlocillin and 64 mg/l for ticarcillin.
Zusammenfassung
Das Verhalten von 56 klinischen Isolaten vonPseudomonas aeruginosa wurde gegenüber folgenden Beta-Laktam-Antibiotika untersucht: Cefotaxim, Cefoperazon, Cefsulodin, Lamoxactam, Ro 13-9904, Azlocillin, Mezlocillin und Ticarcillin. 26 Stämme waren gegen Gentamicin resistent, 30 gegen Gentamicin und/oder Carbenicillin. Die MHK wurde im Reihenverdünnungstest auf Agar bestimmt. Cefsulodin war das wirksamste Cephalosporin gegen die Carbenicillin-resistenten Stämme (MHK ≥ 128 mg/l). Es hemmte 56,6% der getesteten Stämme bei der Grenzkonzentration von 8 mg/l. Azlocillin war das wirksamste der untersuchten Penicilline. Es hemmte 79,96% der Isolate bei Konzentrationen von 64 mg/l. Gegen die Gentamicin-resistente (MHK ≥ 8 mg/l), Carbenicillin-empfindliche (MHK ≤ 64 mg/l) Gruppe vonPseudomonas aeruginosa war Cefuslodin das wirksamste Cephalosporin. Es hemmte alle diese Stämme bei 4 mg/l. Alle drei untersuchten Penicilline hemmten ebenfalls 100% dieser Stämme. Azlocillin bei 16 mg/l, Mezlocillin bei 32 mg/l und Ticarcillin bei 64 mg/l.
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Aisa, M.L., Omenaca, M., Bergua, C. et al. The in vitro activity of beta-lactam antibiotics against gentamicin and/or carbenicillin-resistant pseudomonas aeruginosa strains. Infection 10 (Suppl 3), S244–S248 (1982). https://doi.org/10.1007/BF01640682
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DOI: https://doi.org/10.1007/BF01640682