Zusammenfassung
In Probandenstudien wurden die Wirkungen des Cephalosporins Cefoxitin, ergänzend zu früheren Untersuchungen mit sechs weiteren Cephalosporinen, auf den proximalen Tubulus untersucht. Als Parameter diente die Ausscheidung der Alanin-Aminopeptidase im Harn, ein Membranenzym der Bürstensaummembran des proximalen Tubulus. Dabei zeigte sich, daß die Cephalosporine nahezu keine tubulotoxische Potenz besitzen. In diesen Untersuchungen blieben die möglichen Wirkungen auf die vorgeschädigte Niere und eine längere Therapiedauer über drei Tage hinaus unberücksichtigt.
Summary
Supplementary to previous investigations with six other cephalosporins, the effect of the cephalosporin cefoxitin on the proximal tubule was examined in volunteers. The excretion in the urine of alanine aminopeptidase, a membrane enzyme of the brush border membrane of the proximal tubule, was used as parameter. It was seen that the cephalosporins have almost no toxic effect on the tubule. Therapy of more than three days' duration and the possible effects on the impaired kidney were not considered in this study.
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Mondorf, A.W., Hundt, J., Soder, G.F. et al. Untersuchungen zur Frage tubulotoxischer Wirkungen von Cephalosporinen. Infection 7 (Suppl 1), S116–S118 (1979). https://doi.org/10.1007/BF01639479
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DOI: https://doi.org/10.1007/BF01639479