Summary
Twenty-one patients with disseminated malignant melanoma were treated with a combination of carboplatin and cytosine arabinoside. Two complete and three partial remissions occurred. No complete cross-resistance was found with a regimen containing 5-(dimethyltriazeno)imidazole-4-carboxamide (DTIC) in two patients. It is suggested that this regimen might be studied further as a second-line treatment for patients who fail on DTIC-containing treatment.
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Abbreviations
- DTIC:
-
5-(dimethyltriazeno)imidazole-4-carboxamide
- AraC:
-
cytosine arabinoside
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Mulder, N.H., Sleijfer, D.T., de Vries, E.G.E. et al. Phase II study of carboplatin and cytosine arabinoside in patients with disseminated malignant melanoma. J Cancer Res Clin Oncol 116, 301–302 (1990). https://doi.org/10.1007/BF01612907
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DOI: https://doi.org/10.1007/BF01612907