Abstract
The expression of adhesion molecules by endothelial cells (EC) of early human decidua was studied with monoclonal antibodies and the immunoperoxidase technique. Although E-selectin, INCAM-110 and VCAM-1 were poorly detected on decidual EC, ICAM-1, P-selectin and DR antigens were highly expressed by these cells, some of which showed high endothelial venule-like morphology. Our results suggest that decidual EC are activated, and are probably involved in the active recruitment of leucocytes.
Similar content being viewed by others
References
Bevilacqua MP, Pober JS, Mendrick DL, Cotran RS, Gimbrone MA (1987) Identification of an inducible endothelial-leukocyte adhesion molecule. Proc Natl Acad Sci USA 84:9238–9242
Bulmer JM (1989) Decidual cellular responses. Curr Opin Immunol 1:1141–1147
Bulmer JM, Morrison L, Smith JC (1988) Expression of class II MHC gene products by macrophages in human uteroplacental tissue. Immunology 83:707–714
Castilla JA, Rueda R, Vargas ML, Gonzalez-Gomez F, Garcia-Olivares E (1989) Decreased levels of circulating CD4+ T lymphocytes during normal human pregnancy. J Reprod Immunol 15:103–111
Castilla JA, Vargas ML, Garcia-Tortosa C, Garcia-Pacheco M, Gonzalez-Gomez F, Garcia-Olivares E (1990) Short-lived suppressor cell activity during normal human pregnancy. J Reprod Immunol 18:139–145
Dustin ML, Rothlein R, Bhan AK, Dinarello CA, Springer TA (1986) Induction by IL 1 and interferon-γ: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J Immunol 137:245–254
Hattori R, Hamilton KK, Fugate RD, McEver RP, Sims PJ (1989) Stimulated secretion of endothelial von Willebrand factor is accompanied by rapid redistribution to the cell surface of the intracellular granule membrane protein GMP-140. J Biol Chem 264:7768–7771
King A, Loke YW (1988) Differential expression of blood-group related carbohydrate antigens by trophoblast subpopulations. Placenta 9:513–521
Masuyama J, Minato N, Kano S (1986) Mechanisms of lymphocyte adhesion to human vascular endothelial cells in culture. T lymphocyte adhesion to endothelial cells through endothelial HLA-DR antigens induced by gamma interferon. J Clin Invest 77:1596–1605
McEver RP, Beckstead JH, Moore KL, Marshall-Carlson L, Bainton DF (1989) GMP-140, a platelet α-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies. J Clin Invest 84:92–99
Moll W, Kunzel W, Herberger J (1975) Hemodynamic implications of hemochorial placentation. Eur J Obstet Gynecol Reprod Biol 5:67–74
Osborn L, Hession C, Tizard R, Vassallo V, Luhowskyj S, Chi-Rosso G, Lobb R (1989) Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes. Cell 59:1203–1211
Patel KD, Zimmerman GA, Prescott SM, McEver RP, McIntyre TM (1991) Oxygen radicals induce human endothelial cells to express GMP-140 and bind neutrophils. J Cell Biol 112:749–759
Pober JS (1988) Cytokine-mediated activation of vascular endothelium. Am J Pathol 133:426–433
Pober JS, Cotran RS (1991) Immunologic interactions of T lymphocytes with vascular endothelium. Adv Immunol 50:261–302
Polley MJ, Phillips ML, Wayner E, Mudelman E, Singhal AK, Hakomori SI, Paulson JC (1991) CD62 and endothelial cellleukocyte adhesion molecule 1 (ELAM-1) recognize the same carbohydrate ligand, sialyl-Lewis x. Proc Natl Acad Sci USA 88:6224–6228
Rice GE, Munro JM, Bevilacqua MP (1990) Inducible cell adhesion molecule 110 (INCAM-110) is an endothelial receptor for lymphocytes. A CD11/CD18-independent adhesion mechanism. J Exp Med 171:1369–1374
Rueda R, Vargas ML, Garcia-Pacheco M, Garcia-Olivares E (1990) Detection of immunoregulatory lipid-like factors in human amniotic fluid. Am J Reprod Immunol 24:40–44
Springer TA (1990) Adhesion receptors of the immune system. Nature 346:425–434
Staunton DE, Dustin ML, Springer TA (1989) Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1. Nature 339:61–64
Tabibzadeh SS, Poubouridis D (1990) Expression of leukocyte adhesion molecules in human endometrium. Am J Clin Pathol 93:183–189
Vargas ML, Santos JL, Ruiz C, Montes MJ, Alemán P, Garcia-Tortosa C, Garcia-Olivares E (1993) Comparison of the proportions of leukocytes in early and term human decidua. Am J Reprod Immunol 29:135–140
Wegmann TG (1990) The cytokine basis for cross-talk between the maternal immune and reproductive systems. Curr Opin Immunol 2:765–769
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tortosa, C.G., Vargas, M.L., Cámara, M. et al. Expression of adhesion molecules by endothelial cells of early human decidua. Vichows Archiv A Pathol Anat 423, 287–290 (1993). https://doi.org/10.1007/BF01606892
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01606892