Abstract
The genetic control of the low response of BSVS mice to streptococcal Group A carbohydrate (GAC) was studied in crosses with responder A/J mice. F1 mice were responders. In the backcross (BSVS × A/J)F1 × BSVS mice, there were equal numbers of anti-GAC responder and nonresponder mice, indicating genetic control by a small number of major loci. The anti-GAC responses of the backcross mice showed no obligate linkage between responder status and A/JH-2 orIgC H alleles. However, it was observed that the average anti-GAC titers were higher in backcross mice heterozygous at these loci. The above data, a lack of low-responder F2 animals, and the segregation of a non-H-2-, non-IgC H -linked locus in the first and second backcross mice, indicate that the defect in the BSVS anti-GAC responsiveness involves three loci: one linked toH-2, another linked toIgC H , and a third locus —tentatively namedIr-GAC- not linked toH-2, IgC H , orHbb.
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Briles, D.E., Krause, R.M. & Davie, J.M. Immune response deficiency of BSVS mice. Immunogenetics 4, 381–392 (1977). https://doi.org/10.1007/BF01575676
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DOI: https://doi.org/10.1007/BF01575676