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Role of thyrotropin-releasing hormone in stress ulcer formation in the rat

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Abstract

The role of the hypothalamic peptide thyrotropin-releasing hormone in stress ulcer formation was investigated. In experiment 1, TRH was peripherally administered (10 μg/kg) to rats subjected to cold-restraint stress and compared to an inactive peptide; in experiment 2,TRH was administered intracerebroventricularly (0.02, 0.1, and 0.5 μg/kg) to rats with no adjunctive experimental stress; in experiment 3, TRH antiserum was given intracerebroventricularly to rats subjected to stress and compared to normal rabbit serum. When TRH was administered subcutaneously in rats subjected to stress, it significantly aggravated ulcer formation, and this effect was inhibited by atropine and vagotomy. When administered intracerebroventricularly, TRH alone induced, in a dose-dependent fashion, the formation of gastric ulcers. TRH antiserum infused intrace-rebroventricularly inhibited ulcer formation induced by cold-restraint stress. In conclusion, TRH seems to play a role in stress ulcer formation, possibly by a cholinergic mediated mechanism.

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Authors and Affiliations

  1. II Clinica Chirurgica, University of Rome “La Sapienza”, Italy

    Nicola Basso MD, Maurizio Bagarani MD, A. Eugene Pekary MD, Alfredo Genco MD & Alberto Materia MD

  2. Endocrinology Section, Medical and Research Services, VA Wadsworth

    Nicola Basso MD, Maurizio Bagarani MD, A. Eugene Pekary MD, Alfredo Genco MD & Alberto Materia MD

  3. University of California Medical Centers, 90073, Los Angeles, California

    Nicola Basso MD, Maurizio Bagarani MD, A. Eugene Pekary MD, Alfredo Genco MD & Alberto Materia MD

Authors
  1. Nicola Basso MD
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  2. Maurizio Bagarani MD
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  3. A. Eugene Pekary MD
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  4. Alfredo Genco MD
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  5. Alberto Materia MD
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This work was supported in part by grants from the National Research Council and the Ministry of Public Instruction.

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Basso, N., Bagarani, M., Pekary, A.E. et al. Role of thyrotropin-releasing hormone in stress ulcer formation in the rat. Digest Dis Sci 33, 819–823 (1988). https://doi.org/10.1007/BF01550969

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  • DOI: https://doi.org/10.1007/BF01550969

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