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Cisapride stimulates propulsive motility patterns in human jejunum

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Abstract

The effects of cisapride on upper gut motility were studied in seven healthy volunteers by means of a novel intraluminal electromyographic technique in a placebo-controlled study. In the interdigestive state, cisapride (10 mg intravenous bolus injection) markedly increased the number of spike bursts. The most obvious effect was observed during the first 5-min period when a nonmigrating phase-3-like activity (stationary phase 3) occurred, which lasted for 2.6±0.4 min. This initial pattern was followed by an intense phase 2 activity, characterized by a 10-fold increase in the number of groups of repetitive spike bursts and a sixfold increase in the number of ultrarapid single propagated spike bursts (ultrarapid peristaltic rushes). Cisapride induces in the human upper gut a remarkable pattern of aborally propagated (peristaltic) contractions, which are very likely responsible for the active propulsion of intestinal contents in the interdigestive state.

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Authors and Affiliations

  1. Center for Gastrointestinal Research, Laboratory of Gastrointestinal Motility, University of Leuven, University Hospital Gasthuisberg, Herestraat 49, 3000, Leuven, Belgium

    G. Coremans MD, PhD, J. Janssens MD, PhD, G. Vantrappen MD, PhD, S. Chaussade MD & P. Ceccatelli MD

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  1. G. Coremans MD, PhD
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  2. J. Janssens MD, PhD
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  3. G. Vantrappen MD, PhD
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  4. S. Chaussade MD
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  5. P. Ceccatelli MD
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Coremans, G., Janssens, J., Vantrappen, G. et al. Cisapride stimulates propulsive motility patterns in human jejunum. Digest Dis Sci 33, 1512–1519 (1988). https://doi.org/10.1007/BF01535939

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  • DOI: https://doi.org/10.1007/BF01535939

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