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Analgesic and antiinflammatory effects of dipyrone in rat adjuvant arthritis model

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Abstract

Dipyrone, a pirazolone derivative, is a known analgesic drag with minor toxic effects associated with its administration. The aim of the present study was to determine the analgesic and antiinflammatory effects of dipyrone in a model of chronic inflammation (adjuvant-induced arthritis in rats). Hind-paw hyperalgesia was detected in arthritic rats from the 10th to the 16th day of observation. Edema development was maximum (twofold increase) at the 14th day of observation compared to control animals and reduced at the 16th day of observation. Dipyrone (1–50 mg/kg) dose-dependently reduced both hind-paw hyperalgesia and edema from arthritic rats. However, it was shown to be more potent as analgesic than antiinflammatory in the present model. In contrast, indomethacin (2 mg/kg) and dexamethasone (0.4 mg/kg) completely inhibited hind-paw hyperalgesia and edema development. Our results indicate that dipyrone reduced the hyperalgesia and edema in arthritic rats by a mechanism not involving release of prostaglandin-like substances. The possibility of dipyrone inducing analgesia in arthritic rats through a peripheral action supports the use of dipyrone as an alternative choice drug for the treatment of pain associated with arthritislike diseases in selected cases.

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References

  1. Insel, P.A. 1990. Analgesic-antipyretics and antiinflammatory agents; drugs employed in the treatment of rheumatoid arthritis and gout.In The Pharmacological Basis of Therapeutics. A. Goodman Gilman, T. Rail, A. S. Nies, and P. Taylor, editors. Pergamon Press, Inc., New York. 638–681.

    Google Scholar 

  2. Vlahov, V., andN. Bacracheva. 1989. Agranulocytosis and dipyrone.Lancet 108:1215.

    Google Scholar 

  3. Weithmann, K. U., andH. G. Alpermann. 1985. Biochemical and pharmacological effects of dipyrone and its metabolites in model systems related to arachidonic acid cascade.Arzneimittelforsch 35:947–952.

    PubMed  Google Scholar 

  4. Frolich, J. C., W. A. Rupp, R. M. Zapf, andM. J. Badian. 1986. The effects of metamizol on prostaglandin synthesis in man.In 100 Years of Pyrazolone Drugs: An Update. K. Brune, editor. Agents and Actions Supplements, Vol. 19, Birkhäuser, Verlag. 155–156.

    Google Scholar 

  5. Lorenzetti, B. B., andS. H. Ferreira. 1985. Model of analgesic action of dipyrone: Direct antagonism of inflammatory hyperalgesiaEur. J. of Pharmacol. 114:375–381.

    Google Scholar 

  6. Campos, D. I., F. Q. Cunha, andS. H. Ferreira. 1988. A new mechanism of action of dipyrone: blockade of the release of a nociceptive factor from macrophages.Braz. J. Med. Biol. Res. 21:565–568.

    PubMed  Google Scholar 

  7. Van Duin, C. T. M., T. Van Essen, andA. S. J. Van Miert. 1975. Mechanism of the antipyretic action of salicylates and pyrazolone derivates.Zbl. Vet. Med. 22:510–519.

    Google Scholar 

  8. Capetola, R. J., D. A. Shriver, andM. E. Rosenthale. 1980. Suprofen, a new peripheral analgesic.J. Pharmacol. Exp. Ther. 214:16–23.

    PubMed  Google Scholar 

  9. Dunnett, C. W. 1964. New tables for multiple comparisons with a control.Biometrics 20:482–491.

    Google Scholar 

  10. Waksman, B. H., C. M. Pearson, andJ. T. Sharp. 1960. Studies of arthritis and other lesions induced in rats by injection of mycobacterial adjuvant. II. Evidence that the disease is a disseminated immunologic response to exogenous antigen.J. Immunol. 85:403–417.

    PubMed  Google Scholar 

  11. Currey, H. L., andM. Ziff. 1967. Suppression of adjuvant disease in the rat by heterologous antilymphocyte globulin.J. Exp. Med. 127:185–203.

    Google Scholar 

  12. Parnham, M. J., andG.-A. Schoester. 1980. The inflammatory response to lymph node cells from adjuvant-diseased rats. Relative contributions of donor and recipient cell populations.J. Pathol. 130:255–263.

    PubMed  Google Scholar 

  13. Tsukano, M., Y. Nawa, andM. Kotani. 1983. Characterization of low dose induced suppressor cells in adjuvant arthritis in rats.Clin. Exp. Immunol. 53:60–66.

    PubMed  Google Scholar 

  14. Berczi, I., E. Nagy, S. L. Asa, andK. Kovacs. 1984. The influence of pituitary hormones on adjuvant arthritis.Arthritis Rheumatol. 27(6):682–688.

    Google Scholar 

  15. Pearson, C. M., andT.-Y. Chang. 1977. The contribution of adjuvant arthritis to the recognition of anti-rheumatic drugs.In Recognition of Anti-rheumatic Drugs. D. C. Dumond and M. K. Jasani, editors. MTP Press Limited, Lancaster, U.K. 229–241.

    Google Scholar 

  16. Colpaert, F. C., T. Meert, P. De Witthand, andP. Schmitt. 1982. Further evidence validating adjuvant arthritis as an experimental model of chronic pain in the rat.Life Sci. 31: 67–75.

    PubMed  Google Scholar 

  17. Brogden, R. N. 1986. Pyrazolone derivatives.Drugs (Suppl. 4):60–70.

    Google Scholar 

  18. Pircio, A. W., C. T. Fedele, andM. E. Bierwagen. 1975. A new method for the evaluation of analgesic activity using adjuvant-induced arthritis in the rat.Eur. J. Pharmacol. 31:207–215.

    PubMed  Google Scholar 

  19. Carlsson, K.-H., andI. Jurna. 1987. The role of descending inhibition in the antinociceptive effects of the pyrazolone derivatives, metamizol (dipyrone) and aminophenazone (“Pyramidon”).Naunyn-Schmiedebergs Arch. Pharmakol. 335:154–159.

    Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology, Biological Science Institute Federal University of Minas Gerais, CEP 31270-010, Belo Horizonte, Brazil

    M. A. K. F. Tatsuo, W. M. Carvalho, C. V. Silva, A. E. G. Miranda & J. N. Francischi

  2. Departmento de Farmacologia Faculdade de Medicina de Ribeirão Preto, USP Ribeirão Preto, sp, Brazil

    S. H. Ferreira

Authors
  1. M. A. K. F. Tatsuo
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  2. W. M. Carvalho
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  3. C. V. Silva
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  4. A. E. G. Miranda
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  5. S. H. Ferreira
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  6. J. N. Francischi
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Tatsuo, M.A.K.F., Carvalho, W.M., Silva, C.V. et al. Analgesic and antiinflammatory effects of dipyrone in rat adjuvant arthritis model. Inflammation 18, 399–405 (1994). https://doi.org/10.1007/BF01534437

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