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Activity of creatine kinase isoenzyme MB in serum and red cell acetylcholinesterase variants in patients with duchenne muscular dystrophy

Isoenzym MB-Aktivitäten der Creatinkinase im Serum und Varianten der Frythrozyten-Acetylcholinesterase bei Patienten mit Muskeldystrophie Typ Duchenne

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Zusammenfassung

Die Aktivitäten der Creatinkinase und des Creatinkinase Isoenzyms MB im Serum sowie Varianten der Erythrozyten-Acetylcholinesterase wurden bei Patienten mit Muskeldystrophie Typ Duchenne (DMD) und anderen Formen sowie bei den Verwandten und gesunden Kontrollpersonen bestimmt. Nur bei Fällen von DMD konnten Creatinkinase-Isoenzyme MB wie auch Varianten der Acetylcholinesterase der Erythrozyten nachgewiesen werden.

Summary

Activity of creatine kinase isoenzyme MB in serum and variants of red cell acetylcholinesterase were determined in patients with Duchenne muscular dystrophy, in other forms of Dystrophy and in family members of Duchenne patients and healthy controls. Creatine kinase isoenzyme MB was observed only in all cases of DMD as well as variants of red cell acetylcholinesterase characterized by so-called inhibitor numbers. Carriers of Duchenne muscular dystrophy can be distinguished from Duchenne patients and healthy controls by estimation of Acetylcholinesterase variants.

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Abbreviations

Ald:

aldolase EC4.1.2.13

CK:

creatine kinase EC2.7.3.2

GOT:

glutamic oxalacetic transaminase EC2.6.1.1

GPT:

glutamic pyruvic transaminase EC2.6.1.2

LDH:

lactic dehydrogenase EC1.1.1.27

MDH:

malic dehydrogenase EC1.1.1.37

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Authors and Affiliations

  1. Institut für Humangenetik der Universität Hamburg, Germany

    H. W. Goedde, H. G. Benkmann, P. K. Das & D. P. Agarwal

  2. Biochemische Forschung E. Merck, Darmstadt

    H. Lang & U. Würzburg

  3. Universitäts-Kinderklinik, Freiburg i. Breisgau

    R. Beckmann

Authors
  1. H. W. Goedde
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  2. H. G. Benkmann
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  3. P. K. Das
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  4. D. P. Agarwal
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  5. H. Lang
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  6. U. Würzburg
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  7. R. Beckmann
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Additional information

This work was supported by Deutsche Forschungsgemeinschaft, Stiftung Volkswagenwerk, Alexander v. Humboldt-Stiftung and Bundesministerium für Forschung und Technologie.

We are particularly grateful to Prof. Dr. H. Harders, Allg. Krankenhaus Heidberg, Prof. Dr. D. Seitz, Allg. Krankenhaus St. Georg, Priv.-Doz. Dr. W. Bernhardt and Dr. D. Leiber, Univ.-Krankenhaus Eppendorf, Hamburg, for making serum specimens available.

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Goedde, H.W., Benkmann, H.G., Das, P.K. et al. Activity of creatine kinase isoenzyme MB in serum and red cell acetylcholinesterase variants in patients with duchenne muscular dystrophy. Klin Wochenschr 55, 215–217 (1977). https://doi.org/10.1007/BF01487713

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  • DOI: https://doi.org/10.1007/BF01487713

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