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Steigerung der myokardialen Kontraktionskraft unter Hypoxiebedingungen durch Glucose-Insulin. Untersuchungen am isolierten Papillarmuskel des Meerschweinchenherzens

Increase of force of concentration under hypoxic conditions by glucose-insulin. Experiments in isolated papillary muscles of the guinea pig

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Summary

The minimally remaining force of contraction under the influence of hypoxia was measured in isolated right-ventricular papillary muscles of the guinea-pig, incubated in hypoxic (pO2 90 mm Hg) and oxygenated (pO2 630 mm Hg) buffer solution. With insulin (0.05 IE/ml) and elevated glucose (300 mg% compared to 100 mg%) the force of contraction fell to only 70±9% minimally instead of 38±11% (control,p<0,001). Elevated glucose or insulin alone had less pronounced effects which were not statistically significant for insulin.

The results show an increase of tolerance against hypoxia of isolated papillary muscles under the influence of glucose and insulin.

Zusammenfassung

Die minimal verbleibende Kontraktionskraft unter dem Einfluß von Hypoxie wurde an isolierten, rechtsventrikulären Papillarmuskeln (Meerschweinchen) gemessen, die kurzdauernd (90 s) mit hypoxischem (pO2 90 mm Hg) statt oxygeniertem (pO2 630 mm Hg) Medium inkubiert wurden. Unter dem Einfluß von Insulin (0,05 IE/ml) bei erhöhter Glucosekonzentration (300 mg% im Vergleich mit 100 mg%) sank die Kontraktionskraft minimal nur auf 70±9% im Vergleich mit 38±11% des Ausgangswertes (Kontrolle,p<0,001). Eine alleinige Erhöhung der Glucosekonzentration oder Zugabe von Insulin hatte geringere Effekte zur Folge.

Diese Befunde dokumentieren eine erhebliche Steigerung der Hypoxietoleranz des Myokards durch Glucose-Insulin.

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Authors and Affiliations

  1. Klinikum Großhadern, Medizinische Klinik I der Universität München, Germany

    Th. von Arnim & H. -D. Bolte

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  1. Th. von Arnim
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  2. H. -D. Bolte
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Mit Unterstützung der Deutschen Forschungsgemeinschaft

Technische Assistenz: M. Rupff

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von Arnim, T., Bolte, H.D. Steigerung der myokardialen Kontraktionskraft unter Hypoxiebedingungen durch Glucose-Insulin. Untersuchungen am isolierten Papillarmuskel des Meerschweinchenherzens. Klin Wochenschr 57, 357–359 (1979). https://doi.org/10.1007/BF01476566

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  • DOI: https://doi.org/10.1007/BF01476566

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