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Chromatin-Matrizenaktivität und Verhalten DNA-abhängiger RNA-Polymerase III in der Peri- und Postnatalperiode

Template activity of chromatin and DNA-dependent RNA polymerase III during postnatal development

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Summary

The template-activity of chromatin isolated from liver nuclei of developing rats increases sharply at birth and decreases remarkable until the 10th day. Between the 10th and the 40th day a slow increase was shown in template activity of chromatin tested with purified E.-coli RNA-polymerase (EC 2.7.7.6). We correlated these findings with changes of RNA-polymerase III-activity in rat liver during development.

Zusammenfassung

Die Matrizenaktivität von Chromatin aus gereinigten Rattenleberzellkernen ist in der Fetalzeit niedrig, erreicht ihr Maximum um den 1. Lebenstag und steigt nach einem vorübergehenden Absinken vom 10.–40. Lebenstag allmählich auf Erwachsenenwerte an. Dieser Befund läßt sich mit entwicklungsspezifischen Aktivitätsveränderungen der DNA-abhängigen RNA-Polymerase III im Cytoplasma der Leberzelle gut korrelieren.

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Literatur

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Authors and Affiliations

  1. Strahlenklinik und Kinderklinik der Universität Marburg, Germany

    N. van der Meulen, K. Lipp, G. Wenske & R. Stössel

  2. Universitäts-Kinderklinik, Humboldtallee 38, D-3400, Göttingen, Bundesrepublik Deutschland

    N. van der Meulen

Authors
  1. N. van der Meulen
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  2. K. Lipp
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  3. G. Wenske
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  4. R. Stössel
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van der Meulen, N., Lipp, K., Wenske, G. et al. Chromatin-Matrizenaktivität und Verhalten DNA-abhängiger RNA-Polymerase III in der Peri- und Postnatalperiode. Klin Wochenschr 54, 449–450 (1976). https://doi.org/10.1007/BF01470932

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  • DOI: https://doi.org/10.1007/BF01470932

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