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DNA metabolism in anucleated human blood platelets?

DNA-Stoffwechsel in kernlosen menschlichen Blutplättchen?

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Summary

Thymidine kinase (ATP: thymidine-2′-phosphotransferase, E.C. 2.7.1.21) was demonstrated in human blood platelets. As the enzyme is bound to the organelles, it seems to be a mitochondrial isoenzyme. Due to the fact that thymidine kinase and the DNA metabolism are highly correlated, the presence of (mitochondrial) DNA in human blood platelets is most likely.

Zusammenfassung

Thymidinkinase-Aktivität (ATP: Thymidin-2′-phosphotransferase, E.C. 2.7.1.21) konnte im Homogenat menschlicher Blutplättchen nachgewiesen werden. Da das Enzym organellengebunden ist, könnte es sich um das mitochondriale Isoenzym handeln. Aufgrund der engen Wechselbeziehung zwischen Thymidinkinase und DNA-Stoffwechsel ist auch die Anwesenheit (mitochondrialer) DNA im Thrombocyten zu folgern.

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Schneider, W., Doenecke, C. & Scheurlen, P.G. DNA metabolism in anucleated human blood platelets?. Klin Wochenschr 51, 415–416 (1973). https://doi.org/10.1007/BF01468092

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  • DOI: https://doi.org/10.1007/BF01468092

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