Skip to main content
SpringerLink
Log in

Cerebral primitive neuro-ectodermal tumour following treatment of a unilateral retinoblastoma

  • Clinical Articles
  • Published:
Acta Neurochirurgica Aims and scope Submit manuscript

Summary

Cerebral primitive neuro-ectodermal tumour (PNET) occurring as a second primary malignancy in childhood is exceedingly rare. We present a 7-year-old boy who developed a proven supratentorial PNET five years after enucleation and radio-/chemotherapy for a sporadic, unilateral retinoblastoma with optic nerve invasion. The association with this malignant eye disease as well as the effect of irradiation and multi-agent chemotherapy on second tumour induction are evaluated.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Abramson DH, Ellsworth RM, Kitchin D, Tung G (1984) Second nonocular tumors in retinoblastoma survivors. Are they radiation-induced? Ophthalmology 91: 1351–1355

    PubMed  Google Scholar 

  2. Asato R, Akiyama Y, Ito M, Kubota M, Okumura R, Miki Y, Konishi J, Mikawa H (1992) Nuclear magnetic resonance abnormalities of the cerebral white matter in children with acute lymphoblastic leukemia and malignant lymphoma during and after central nervous system prophylactic treatment with intrathecal methotrexate. Cancer 70: 1997–2004

    PubMed  Google Scholar 

  3. Atlas S (1996) MRI of the brain and spine, 2nd ed. Raven, New York, pp 373–378

    Google Scholar 

  4. Bader JL, Meadows AT, Zimmerman LE, Rorke LB, Voute PA, Champion LAA, Miller RW (1982) Bilateral retinoblastoma and ectopic intracranial retinoblastoma. Trilateral retinoblastoma. Cancer Genet Cytogenet 5: 203

    PubMed  Google Scholar 

  5. Ball WS, Prenger EC, Ballard ET (1992) Neurotoxicity of radio/chemotherapy in children: Pathologic and MR correlation. Am J Neuroradiol 13: 761–776

    PubMed  Google Scholar 

  6. Barasch ES, Altieri D, Decker RE, Ahmed S, Lin J (1988) Primitive neuroectodermal tumor presenting as a delayed sequela to cranial irradiation and intrathecal methotrexate. Pediatr Neurol 4: 375–378

    PubMed  Google Scholar 

  7. Bernstein M, Laperriere N (1991) Radiation-induced tumors of the nervous system. In: Gutin PH, Leibel SA, Sheline GE (eds) Radiation injury to the nervous system. Raven, New York, pp 455–472

    Google Scholar 

  8. Brüstle O, Ohgaki H, Schmitt HP, Walter GF, Ostertag H, Kleihues P (1992) Primitive neuroectodermal tumors after prophylactic central nervous system irradiation in children. Association with an activated K-ras gene. Cancer 69: 2385–2392

    PubMed  Google Scholar 

  9. Cahan WG, Woodard HQ, Higinbotham NL, Stewart FW, Coley BL (1948) Sarcoma arising in irradiated bone: Report of eleven cases. Cancer 1: 3–29

    Google Scholar 

  10. Corn BW, Yousem DM, Scott CB, Rotman M, Asbell SO, Nelson DF, Martin L, Curran WJ (1994) White matter changes are correlated significantly with radiation dose. Cancer 74: 2828–2835

    PubMed  Google Scholar 

  11. DerKinderen DJ, Koten JW, Nagelkerke NJD, Tan KEWP, Beemer FA, Den Otter W (1988) Non-ocular cancer in patients with hereditary retinoblastoma and their relatives. Int J Cancer 41: 499–504

    PubMed  Google Scholar 

  12. Draper GJ, Sanders BM, Kingston JE (1986) Second primary neoplasms in patients with retinoblastoma. Br J Cancer 53: 661–671

    PubMed  Google Scholar 

  13. Eng C, Li FP, Abramson DH, Ellsworth RM, Wong FL, Goldman MB, Seddon J, Tarbell N, Boice JD Jr (1993) Mortality from second tumors among long-term survivors of retinoblastoma. J Natl Cancer Inst 85: 1121–1128

    PubMed  Google Scholar 

  14. Harris CC (1975) Immunosuppressive anti-cancer drugs in man: Their oncogenic potential. Radiology 114: 163–166

    PubMed  Google Scholar 

  15. Hart MN, Earle KM (1973) Primitive neuroectodermal tumors of the brain in children. Cancer 32: 890–897

    PubMed  Google Scholar 

  16. Hazuka MB, Kinzie JJ, Davis KA, DeBoise DA (1989) Treatment-related central nervous system toxicity: MR imaging evaluation with CT and clinical correlation. Magn Reson Imaging 7: 669–676

    PubMed  Google Scholar 

  17. Howarth C, Meyer D, Omar Hustu H, Johnson WW, Shanks E, Pratt C (1980) Stage-related combined modality treatment of retinoblastoma. Results of a prospective study. Cancer 45: 851–858

    PubMed  Google Scholar 

  18. Jakobiec FA, Tso MOM, Zimmerman LZ, Danis P (1977) Retinoblastoma and intracranial malignancy. Cancer 39: 2048–2058

    PubMed  Google Scholar 

  19. Knudson AG: Mutation and Cancer (1971) Statistical study of retinoblastoma. Proc Natl Acad Sci USA 68: 820–823

    PubMed  Google Scholar 

  20. Lee W-H, Bookstein R, Hong F, Young L-J, Shew J-Y, Lee EY-HP (1987) Human retinoblastoma susceptibility gene: cloning, identification, and sequence. Science 235: 1394–1399

    PubMed  Google Scholar 

  21. Liwnicz BH, Berger TS, Liwnicz RG, Aron BS (1985) Radiation-associated gliomas: a report of four cases and analysis of postradiation tumors of the central nervous system. Neurosurgery 17: 436–445

    PubMed  Google Scholar 

  22. Long SD, Kuhn MJ (1992) Primitive neuroectodermal tumor: CT, MRI, and angiographic findings. Comput Med Imag Graph 16: 291–295

    Google Scholar 

  23. Marus G, Levin V, Rutherfoord GS (1986) Malignant glioma following radiotherapy for unrelated primary tumors. Cancer 58: 886–894

    PubMed  Google Scholar 

  24. Modan B, Mart H, Baidatz D, Steinitz R, Levin SG (1974) Radiation-induced head and neck tumours. Lancet I: 277–279

    Google Scholar 

  25. Neglia JP, Meadows AT, Robison LL, Kim TH, Newton WA, Ruymann FB, Sather HN, Hammond GD (1991) Second neoplasms after acute lymphoblastic leukemia in childhood. New Engl J Med 325: 1330–1336

    PubMed  Google Scholar 

  26. Pesin SR, Shields JA (1989) Seven cases of trilateral retinoblastoma. Am J Ophthalmol 107: 121–126

    PubMed  Google Scholar 

  27. Rimm IL, Li FC, Tarbell NJ, Winston KR, Sallan SE (1987) Brain tumors after cranial irradiation for childhood acute lymphoblastic leukemia: A 13-year experience from Dana-Farber Cancer Institute and The Children's Hospital. Cancer 59: 1506–1508

    PubMed  Google Scholar 

  28. Roarty JD, McLean IW, Zimmerman LE (1988) Incidence of second neoplasms in patients with bilateral retinoblastoma. Ophthalmology 95: 1583–1587

    PubMed  Google Scholar 

  29. Romanowski R, Timmermann M, Höpping W, Sauerwein W, Bornfeld N, Havers W (1992) Second tumors in retinoblastoma patients. Med Pediatr Oncol 20: 465 (abstract P297)

    Google Scholar 

  30. Ron E, Modan B, Boice JD, Alfandary E, Stovall M, Chetrit A, Katz L (1988) Tumors of the brain and nervous system after radiotherapy in childhood. N Engl J Med 319: 1033–1039

    PubMed  Google Scholar 

  31. Salvati M, Artico M, Caruso R, Rocchi G, Orlando ER, Nucci F (1991) A report on radiation-induced gliomas. Cancer 67: 392–397

    PubMed  Google Scholar 

  32. Soffer D, Pittaluga S, Feiner M, Beller AJ (1983) Intracranial meningiomas following low-dose irradiation to the head. J Neurosurg 59: 1048–1053

    PubMed  Google Scholar 

  33. Tiberin P, Maor E, Zaizov R, Cohen IJ, Hirsch M, Yosefovich T, Ronen J, Goldstein J (1984) Brain sarcoma of meningeal origin after cranial irradiation in childhood acute lymphocytic leukemia. Case report. J Neurosurg 61: 772–776

    Google Scholar 

  34. Tsuruda JS, Kortman KE, Bradley WG, Wheeler DC, Van Dalsem W, Bradley TP (1987) Radiation effects on cerebral white matter: MR evaluation. Am J Neuroradiol 8: 431–437

    Google Scholar 

  35. Winther J, Olsen JH, De Nully Brown P (1988) Risk of nonocular cancer among retinoblastoma patients and their parents. A population-based study in Denmark, 1943–1984. Cancer 62: 1458–1462

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Clinic of Neurosurgery, Klagenfurt

    G. Dorfmüller M. D. & G. Lanner

  2. Institute of Pathology, Klagenfurt

    F. G. Würtz

  3. Institute of Neuropathology, University of Graz, Austria

    R. Kleinert

Authors
  1. G. Dorfmüller M. D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. G. Würtz
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. Kleinert
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. Lanner
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dorfmüller, G., Würtz, F.G., Kleinert, R. et al. Cerebral primitive neuro-ectodermal tumour following treatment of a unilateral retinoblastoma. Acta neurochir 139, 749–755 (1997). https://doi.org/10.1007/BF01420048

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01420048

Keywords

Search

Navigation