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Brain energy metabolism in the acute stage of experimental subarachnoid haemorrhage: Local changes in cerebral glucose utilization

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Summary

An experimental model was used to investigate acute alterations of cerebral metabolic activity in rats subjected to subarachnoid haemorrhage (SAH). Haemorrhages were produced in anaesthetized animals by injecting 0.3 ml of autologous, arterial nonheparinized blood into the cisterna magna. Control rats received subarachnoid injections of mock-cerebrospinal fluid to study the effect of sudden raised intracranial pressure, or underwent sham operation. Three hours after SAH rats were given an intravenous injection of [14C]-2-deoxyglucose. Experiments were terminated by decapitation, and the brains were removed and frozen. Regional brain metabolic activity was studied by quantitative autoradiography. In comparison with sham-operated controls, cerebral metabolic activity was diffusely decreased after SAH. Statistically significant decreases in metabolic rate were observed in 23 of 27 brain regions studied. Subarachnoid injections of mock-cerebrospinal fluid also produced depression of cerebral metabolic activity, but quantitatively these changes were not as pronounced and diffuse as in SAH rats. The present study shows that a widespread depression of brain metabolism occurs in the acute stage after experimental SAH and is probably secondary to the Subarachnoid presence of blood itself and/or blood products.

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Authors and Affiliations

  1. Neurosurgical Clinic, University of Messina Medical School, Messina, Italy

    D. d'Avella, A. Romano, F. F. Angileri, F. M. Salpietro & F. Tomasello

  2. Institute of Oncology, University of Messina Medical School, Messina, Italy

    R. Cicciarello & F. Albiero

  3. Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA

    M. Zuccarello

Authors
  1. D. d'Avella
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  2. R. Cicciarello
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  3. M. Zuccarello
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  4. F. Albiero
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  5. A. Romano
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  6. F. F. Angileri
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  7. F. M. Salpietro
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  8. F. Tomasello
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d'Avella, D., Cicciarello, R., Zuccarello, M. et al. Brain energy metabolism in the acute stage of experimental subarachnoid haemorrhage: Local changes in cerebral glucose utilization. Acta neurochir 138, 737–744 (1996). https://doi.org/10.1007/BF01411481

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