Skip to main content
SpringerLink
Log in

Effects of carvedilol on common carotid arterial flow, peripheral hemodynamics, and hemorheologic variables in hypertension

  • Poster Presentations
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

Summary

The effects of a beta-blocker, carvedilol, on peripheral hemodynamics and hemorheologic parameters were evaluated in 11 geriatric patients with essential hypertension [3 men and 8 women aged 62–79 years (mean, 68.6 years)]. Carvedilol was given orally after breakfast at a dose of 10 or 20 mg daily for 8 weeks. Peripheral hemodynamics, the common carotid arterial flow, and hemorheologic parameters were determined twice prior to administration and after 4 and 8 weeks of carvedilol treatment. The common carotid arterial flow was determined using the pulsed Doppler method. Peripheral hemodynamics were assessed by venous occlusion plethysmography. The hemorheologic parameters assessed include erythrocyte aggregation, erythrocyte deformability, plasma viscosity, whole-blood hematocrit, and platelet function tests. Erythrocyte aggregation was measured using an Erythrocyte Aggregometer MA-1 (Myrenne, USA), taking a high shear rate of 600 s\t-1 and a low shear rate of 3 s\t-1 as the indices. Statistical comparisons of values before and after carvedilol administration were made using the paired Student'st-test. Systolic and diastolic blood pressure were decreased by carvedilol. The common carotid arterial flow was increased, and peripheral hemodynamics were improved by carvedilol. Erythrocyte aggregation (measured at both a high and a low shear rate) and plasma viscosity were decreased, erythrocyte deformability was increased, and levels of circulating platelet aggregates were also improved by carvedilol. This improvement of hemorheologic variables may contribute to prevention of the initiation and progression of thrombosis and atherosclerosis in geriatric patients with essential hypertension.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Moellendorff E van, Abshagen U, Akpan W, Neugebauer G, Schroeter E (19869 Clinical pharmacologic investigations with carvedilol, a new beta-blocker with direct vasodilator activity. Clin Pharmacol Ther 39: 677–682

    Google Scholar 

  2. Strein K, Sponer B, Mueller-Beckmann B, Bartsch W (1987) Pharmacological profile of a carvedilol, a compound with beta-blocking and vasodilating properties. J Cardiovasc Pharmacol 10 [Suppl 11]: S33-S41

    Google Scholar 

  3. Abshagen U (1987) A new molecule with vasodilating and beta-adrenoceptor blocking properties. J Cardiovasc Pharmacol 10 [Suppl 11]: S23-S32

    Google Scholar 

  4. Cubeddu LX, Fuenmayer N, Varin F, Villagra VG, Colindres RE, Powell JR (1987) Mechanism of the vasodil-ory effect of carvedilol in normal volunteers: a comparison with labetaolol. J Cardiovasc Pharmacol 10 [Suppl 11]: S81-S84

    Google Scholar 

  5. Hashimoto H, Tanaka M, Kanda A, Akashi A (1988) Analysis of the mechanism underlying the vasodilator action of carvedilol in pithed spontaneously hypertensive rats. Drugs 26 [Suppl 6]: 31–36

    Google Scholar 

  6. Hattori Y, Nakaya H, Endou M, Nakao Y, Kanno M (1989) Vascular effects of carvedilol, a new beta-adrenoceptor antagonist with vasodilating properties, in isolated canine coronary artery. J Cardiovasc Pharmacol 13: 572–579

    Google Scholar 

  7. Sponer G, Bartsch W, Strein K, Mueller-Beckmann B, Peters P (1985) Hemodynamic profile of carvedilol and propranolol in conscious spontaneously hypertensive rats and normotensive dogs. International Cardiovascular Pharmacotherapy Symposium, May 22–25,1985, Geneva

  8. Nagakawa Y, Onuki Y, Orimo H, Harasawa M (1986) Pulsed Doppler: diameter, blood flow velocity and volume flow of the common carotid artery in cerebral infarction. Jpn J Stroke 8: 600–602

    Google Scholar 

  9. Nagakawa Y, Orimo H, Harasawa M (1984) Effect of age, sex and other physical parameters on peripheral hemodynamics in normal subjects. J Cardiogr 14 [Suppl V]: 76–78

    Google Scholar 

  10. Reid HL, Barnes AJ, Lock PJ, Dormandy JA, Dormandy TL (1976) A simple method for measuring erythrocyte deformability. J Clin Pathol 29: 855–858

    PubMed  Google Scholar 

  11. Schmid-Schoenbein H, Kline KA, Heinlich L, Volger E, Fischer T (1975) Microrheology and light transmission of blood: velocity of red cell aggregate formation. Pfluegers Arch 354: 299–317

    Google Scholar 

  12. Nagakawa Y (1980) Factors influencing the platelet aggregation test. Jpn J Geriatr 17: 7–17

    Google Scholar 

  13. Wu KK, Hoak JC (1974) A new method for the quantitative detection of platelet aggregates in patients with arterial insufficiency. Lancet II: 924–926

    Google Scholar 

  14. Chien S (1977) Blood rheology in hypertension and cardiovascular diseases. Cardiovasc Med 2: 356–360

    Google Scholar 

  15. Dintenfass L (1977) Viscosity factors in hypertensive and cardiovascular diseases. Cardiovasc Med 2: 337–342

    Google Scholar 

  16. Letcher RL, Chien S, Pickering TG, Sealey JE, Laragh JH (1981) Direct relationship between blood pressure and blood viscosity in normal and hypertensive subjects: role of fibrinogen and concentration. Am J Med 70: 1195–1202

    PubMed  Google Scholar 

  17. Jan KM, Chien S, Bigger IT Jr (1975) Observations on blood viscosity changes after acute myocardial infarction. Circulation 51: 1079–1084

    PubMed  Google Scholar 

  18. Forconi S, Guerrini M, Pieragalli D, Acciavatti A, DelBigo C, Galigani C, Diperri T (1983) Hemorheological changes in ischemic heart disease. Ric Clin Lab 13 [Suppl 3]: 195–208

    PubMed  Google Scholar 

  19. Chien S (1975) Biophysical behavior of red cells in suspsensions. In: Surgenor DM (ed) The red blood cell, vol 2, 2nd edn. Academic Press, New York, pp 1031–1133

    Google Scholar 

  20. Gaetano G de, Bertele V, Cerletti C (1987) Pharmacology of antiplatelet drugs. In: MacIntyre DE, Gordon JL (eds) Platelets in biology and pathology III. Elsevier Science, Amsterdam New York Oxford

    Google Scholar 

  21. Scott CK, Persico FJ, Carpentier K, Chasin M (1980) The effect of flunarizine, a new calcium antagonist, on human red blood cells in vitro. Angiology 31: 320–330

    Google Scholar 

  22. Van Neuten JM, Vanhoutte PM (1980) Improvement of tissue perfusion with inhibitors of calcium ion influx. Biochem Pharmacol 29: 479–481

    PubMed  Google Scholar 

  23. Plishker GA, Gitelman HJ (1977) Calcium dependent ATP losses in intact red blood cells without cellular accumulations of calcium. J Membrane Biol 35: 309–318

    Google Scholar 

  24. Larsen FL, Katz S, Roufogalis BD, Brooks DE (1981) Physiological shear stresses enhance the Ca2+ permeability of human erythrocytes. Nature 294: 667–668

    PubMed  Google Scholar 

  25. Quist EE (1980) Regulation of erythrocyte membrane shape by calcium. Biochem Biophys Res Commun 92: 631–637

    PubMed  Google Scholar 

  26. Vanhoutte P, Amery A, Birkenhaeger W, Breckenridge A, Buehler F, Distler A, Dormandy J, Doyle A, Fronlich E, Hansson L, Hedner T, Hollenberg N, Jensen HE, Lund-Johansen P, Meyer P, Opie L, Robertson I, Safar M, Schalekamp M, Symoens J, Trap-Jensen J, Zanchetti A (1988) Serotonergic mechanisms in hypertension. Focus on the effects of ketanserin. Hypertension 11: 111–133

    PubMed  Google Scholar 

  27. De Cree J, Leempoels J, Demoen B, Verhaegen H (1985) Ketanserin and red blood cell sodium content in hypertension. J Cardiovasc Pharmacol [Suppl] 7: S41-S43

    Google Scholar 

  28. Fuchs J, Weinberger I, Rotenberg Z, Erdberg A, Davidson E, Joshua H, Agmon J (1984) Plasma viscocity in ischemic heart disease. Am Heart J 108: 435–439

    PubMed  Google Scholar 

  29. Sundberg S, Tiihonen K, Gondin A (1987) Vasodilatory effects of carvedilol and pindolol. J Cardiovasc Pharmacol 10 [Suppl 11]: 76–80

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Geriatrics Faculty of Medicine, University of Tokyo, Hongo 7-3-1 Bunkyo-ku, 113, Tokyo, Japan

    Y. Nagakawa, Y. Akedo, S. Kaku & H. Orimo

Authors
  1. Y. Nagakawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Y. Akedo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Kaku
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H. Orimo
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nagakawa, Y., Akedo, Y., Kaku, S. et al. Effects of carvedilol on common carotid arterial flow, peripheral hemodynamics, and hemorheologic variables in hypertension. Eur J Clin Pharmacol 38 (Suppl 2), S115–S119 (1990). https://doi.org/10.1007/BF01409478

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01409478

Key words

Search

Navigation