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Haemodynamic, intracranial pressure and electrocardiographic changes following subarachnoid haemorrhage in rats

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Summary

Experimental induction of subarachnoid haemorrhage in rats resulted in acute haemodynamic changes. Heart rate decreased concomitantly with a rise in arterial blood pressure. Intracranial pressure increased and consequently cerebral perfusion pressure dropped. These changes as well as the observed electrocardiographic (ECG) changes were comparable to those reported in patients. Apart from blood also saline, when introduced into the cisterna magna, was able to elicit such abnormalities. The haemodynamic and electrocardiographic changes, which result from subarachnoid haemorrhage, may even become aggravated, when repetitive injections of blood or saline are given into the cisterna magna and when cerebral angiography is performed prior to induction of the subarachnoid haemorrhage. Chronic intracranial pressure monitoring during the 48 hours following subarachnoid haemorrhage revealed no significant rise in pressure.

A thorough control of the experimental conditions is thus of utmost importance in order to give a valid interpretation of the observed anomalies.

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References

  1. Andreoli A, di Pasquale G, Pinelli G, Grazi P, Tognetti F, Testa C (1987) Subarachnoid hemorrhage: frequency and severity of cardiac arrhythmias. Stroke 3: 558–564

    Google Scholar 

  2. Breks JWF (1980) Cerebral vasospasm and increased intracranial pressure. In: Wilkins RH (ed) Cerebral arterial spasm. Williams & Wilkins, Baltimore London, pp 412–413

    Google Scholar 

  3. Brouwers PJAM, Wijdicks EFM, Hasan D, Vermeulen M, Wever EFD, Frericks H, van Gijn J (1989) Serial electrocardiographic recording in aneurysmal subarachnoid hemorrhage. Stroke 20: 1162–1167

    PubMed  Google Scholar 

  4. Choo MH, Chia BL, Tan L (1985) Stroke masking electrocardiographic abnormalities. J Electrocardiography 18: 405–408

    Google Scholar 

  5. Cushing H (1902) Some experimental and clinical observations concerning states of increased intracranial tension. Am J Med Sci 124: 375–400

    Google Scholar 

  6. Fentz V, Gormsen J (1962) Electrocardiographic patterns in patients with cerebrovascular accidents. Circulation 25: 22–28

    PubMed  Google Scholar 

  7. Harrison MT, Gibb BH (1964) Electrocardiographic changes associated with a cerebrovascular accident. Lancet 2: 429–430

    Google Scholar 

  8. Hugenholtz PG (1962) Electrocardiographic abnormalities in cerebral disorders. Report of six cases and review of the literature. Am Heart J 63: 451–461

    PubMed  Google Scholar 

  9. Koskelo P, Punsar S, Sipilä W (1964) Subendocardial haemorrhage and ECG changes in intracranial bleeding. Br Med J 1: 1479–1480

    Google Scholar 

  10. Lacy PS, Earle AM (1983) A small animal model for electrocardiographic abnormalities observed after an experimental subarachnoid haemorrhage. Stroke 14: 371–377

    PubMed  Google Scholar 

  11. Marion DW, Segal R, Thompson ME (1986) Subarachnoid hemorrhage and the heart. Neurosurg 18: 101–106

    Google Scholar 

  12. Menon IS (1964) Electrocardiographic changes simulating myocardial infarction in cerebrovascular accident. Lancet 2: 433–434

    Google Scholar 

  13. Nakamura Y, Kaseno K, Kubo T (1989) Transient ST-segment elevation in subarachnoid hemorrhage. J Electrocardiol 22: 133–137

    PubMed  Google Scholar 

  14. Neil-Dwyer G, Cruickshank JM, Doshi R (1990) The stress response in subarachnoid haemorrhage and head injury. Acta Neurochir (Wien) [Suppl] 47: 102–110

    Google Scholar 

  15. Neil-Dwyer G, Walter P, Cruickshank JM, Doshi B, O'Gorman P (1978) Effect of propranolol and phentolamine on myocardial necrosis after subarachnoid haemorrhage. Br Med J 2: 990–992

    PubMed  Google Scholar 

  16. Parizel G (1973) Life-threatening arrhythmias in subarachnoid haemorrhage. Angiology 24: 17–21

    PubMed  Google Scholar 

  17. Solomon RA, Antunes L, Chen RYZ, Bland L, Chien S (1985) Decrease in cerebral blood flow in rats after experimental subarachnoid haemorrhage: a new animal model. Stroke 16: 58–64

    PubMed  Google Scholar 

  18. Srivastava SC, Robson AO (1964) Electrocardiographic abnormalities associated with subarachnoid haemorrhage. Lancet 2: 431–433

    Google Scholar 

  19. Stober T, Anstätt Th, Sen S, Schimrigk K, Jäger H (1988) Cardiac arrhythmias in subarachnoid haemorrhage. Acta Neurochir (Wien) 93: 37–44

    Google Scholar 

  20. Verlooy J, Selosse P, Van Reempts J, Haseldonckx M, Borgers M (1990) Fiberoptic intracranial pressure monitoring in rats. J Neurosci Meth 31: 1–6

    PubMed  Google Scholar 

  21. Verlooy J, Van Reempts J, Haseldonckx M, Borgers M, Selosse P Vertebrobasilar angiography following subarachnoid haemorrhage in rats. Acta Neurochir (Wien), submitted

  22. Weintraub RM, Mc Henry LC (1974) Cardiac abnormalities in subarachnoid haemorrhage. A resume. Stroke 5: 384–392

    PubMed  Google Scholar 

  23. Uchida M, Saito K, Niitsu T, Okuda H (1989) Model of electrocardiographic changes seen with subarachnoid hemorrhage in rabbits. Stroke 20: 112–118

    PubMed  Google Scholar 

  24. Yuki K, Kodama Y, Onda J, Emoto K, Morimoto T, Uozumi T (1991) Coronary vasospasm following subarachnoid haemorrhage as a cause of stunned myocardium. J Neurosurg 75: 308–311

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Neurosurgery, University Hospital Antwerp, Edegem, Belgium

    J. Verlooy & P. Selosse

  2. Department of Life Sciences, Janssen Research Foundation, Beerse, Belgium

    J. Van Reempts, M. Haseldonckx & M. Borgers

Authors
  1. J. Verlooy
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  2. J. Van Reempts
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  3. M. Haseldonckx
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  4. M. Borgers
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  5. P. Selosse
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Verlooy, J., Van Reempts, J., Haseldonckx, M. et al. Haemodynamic, intracranial pressure and electrocardiographic changes following subarachnoid haemorrhage in rats. Acta neurochir 115, 118–122 (1992). https://doi.org/10.1007/BF01406369

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  • DOI: https://doi.org/10.1007/BF01406369

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