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Studies on the passage of water, electrolytes and proteins into the cerebrospinal fluid in the human

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Summary

The passage of tritiated water, some electrolytes and iodinated serum albumin from the plasma into the ventricular and lumbar cerebrospinal fluid has been studied in normal humans during a period of time from between 50–70 hours.

The pattern of sodium and chloride ion absorption seems to be of particular significance since these electrolytes are actively concentrated in the cerebrospinal fluid.

Zusammenfassung

Bei normalen Versuchspersonen wurde die Passage von Tritium-Wasser, einigen Elektrolyten und jodiertem Serum-Albumin vom Plasma zum Ventrikel- und Lumballiquor untersucht. Die Beobachtungszeit betrug 50 bis 70 Stunden.

Die Art des Übertritts der Natrium- und Chlor-Ionen scheint von besonderer Bedeutung, weil diese Elektrolyte aktiv im Liquor konzentriert werden.

Résumé

Les auteurs ont étudié le passage du plasma au liquide céphalorachidien ventriculaire et lombaire de l'eau tritiée, de quelques électrolytes et de l'albumine-I131 chez des sujets normaux.

La discussion est particulièrement poussée sur le comportement du Na+ et du Cl− qui sont activement concentrés dans le liquide céphalorachidien; cette observation semble très importante pour discuter la production du liquide.

Riassunto

Gli autori espongono i risultati ottenuti studiando in soggetti normali il passaggio dell'acqua tritiata, di alcuni elettroliti marcati, e della siero albumina-I131, dal plasma al liquor cerebrospinale ventricolare e lombare.

Il particolare comportamento del Na+ e del Cl−, che si accumulano nel liquor rispetto al plasma, viene discusso quale possibile meccanismo di produzione del liquor.

Resumen

Los autores exponen los resultados obtenidos en sujetos normales estudiando el paso del agua tritiada, de algunos electrolitos marcados y de la albúmina-I131 desde la sangre al liquido cerebroespinal ventricular y lumbar.

Se discute particularmente el comportamiento del Na+ y del Cl− que se acumulan mas activamente en el liquido cefalo-raquideo, se discuten también los posibles mécanismos de producción del líquido.

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Authors and Affiliations

  1. Neurosurgical Clinic, University of Milano, Italy

    A. Migliore M. D., P. Paoletti M. D. & R. Villani M. D.

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  1. A. Migliore M. D.
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  2. P. Paoletti M. D.
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  3. R. Villani M. D.
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Migliore, A., Paoletti, P. & Villani, R. Studies on the passage of water, electrolytes and proteins into the cerebrospinal fluid in the human. Acta neurochir 12, 1–10 (1964). https://doi.org/10.1007/BF01404698

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