Abstract
The effects of calcium antagonists (nifedipine, nicardipine, diltiazem, and verapamil) and prostaglandin E1 (PGE1) on the tension of isolated canine coronary arterial strips were studies. In a solution containing 20 mEq/L of K+, 127 mEq/L of Na+, the tension was increased by 500–1,000 mg with 4 mEq/L of Ca2+. This increase in tension was suppressed by Ca-antagonists and PGE1 dose-dependently. Nifedipine 10−5 M, nicardipine 3 X 10−7 M, diltiazem 3 X 10−6 M, and verapamil 3 X 10−6 M completely suppressed the increased tension. The maximal suppression of the tension produced by PGE1 was about 40% at 10−10 M. In 20 mEq/L K+ solution (0 mEq/L Ca2+, 37°C), the reduction of the Na+ concentrations from 127 mEq/L to 12 mEq/L increased the tension by 50 to 100 mg. This increase in tension was not suppressed by Ca-antagonists or PGEI. In conclusion, this study demonstrated that Ca-antagonists and PGE1 suppressed an increase in the tension caused by Ca2+ but did not suppress an increase in the tension caused by Na+ reduction.
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Yoshida K, Fujii Y, Ina H, Fujioka S, Maseki T, Abe T, Tokuno H, Tomita T (1991) Effects of sodium and temperature on tension of isolated canine coronary artery. J Anesth 5:56–59
Yoshida K, Fujii Y, Ina H, Fujioka S, Maseki T, Abe T, Tokuno H, Tomita T (1991) Effects of calcium and temperature on tension in isolated canine coronary artery. J Anesth 5:172–176
Henry PD (1980) Comparative pharmacology of calcium antagonists. Nifedipine, verapamil and diltiazem. Am J Cardiol 46:1047–1058
Horrobin DF (1988) Prostaglandin E1. Physiological significance and clinical use. Wien Klin Wochenschr 100:471–477
Triggle DJ, Swamy VC (1980) Pharmacology of agents that affect calcium. Agonists and antagonists. Chest78:174–179
Nowycky MC, Fox AP, Tsien RW (1985) Three types of neuronal calcium channel with different calcium agonist sensitivity. Nature 316:440–443
Zelis R, Wichmann T, Starke K (1985) Inhibition by diltiazem of norepinephrine release from sympathetic nerves in the rabbit pulmonary artery. Pharmacology 31:268–277
Miller RJ (1987) Multiple calcium channels and neuronal function. Science 235:46–52
Imai S, Takeda K (1967) Actions of calcium and certain multivalent cations on potassium contracture of guinea-pig's taenia coli. J Physiol 190:155–169
Zelis R, Moore R (1989) Recent insights into the calcium channels. Circulation 80 [Suppl 4]:14–16
Hiremath AN, Pershe RA, Hoffman BB, Blaschke TF (1989) Comparison of age-related changes in prostaglandin E, and beta-adrenergic reponsiveness of vascular smooth muscle in adult males. J Gerontol 44:M13-M17
Exon JH (1988) Mechanisms of action of calcium-mobilizing agonists. Some variations on a young theme. FASEB J 2:2670–2676
Kinoshita K, Ehara T (1984) Importance of sodium ions in the prospective effects of high-potassium, high-glucose solution on electromechanical activities in the guinea-pig myocardium. J Mol Cell-Gardiol 16:405–419
Blaustein MP (1977) Sodium ions, calcium ions, blood pressure regulation, and hypertension. A reassessment and a hypothesis. Am J Physiol 232:C165-Cl73
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Yoshida, K., Iwase, J., Murakami, F. et al. The effects of calcium antagonists and prostaglandin El on isolated canine coronary arterial tension. Surg Today 24, 1073–1077 (1994). https://doi.org/10.1007/BF01367458
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DOI: https://doi.org/10.1007/BF01367458