Skip to main content
SpringerLink
Log in

Antigenic relationships between field isolates of morbilliviruses from different carnivores

  • Original Papers
  • Published:
Archives of Virology Aims and scope Submit manuscript

Summary

The antigenic relationships between PDV and isolates of morbilliviruses from carnivores suffering from distemper were investigated. Fourteen isolates, originating from terrestrial carnivores and harbour seals from 1985–1991 from Denmark, Norway, Greenland, and the U.S.A. were reacted in IFA and ELISA with monoclonal antibodies (MAbs) directed against four virion proteins (NP, P, F, and H). The MAbs comprised a newly completed panel of 36 anti-PDV MAbs and 39 previously developed anti-CDV MAbs. The antigenic make-up of the isolates separated them into the CDV prototype group and the PDV prototype group, having the antigenic characteristics of the reference vaccine strains of CDV and the Danish PDV isolate, respectively. The minor antigenic variations within the CDV group contrasted markedly to the differences encountered between the CDV and PDV group. The PDV group included isolates made in 1988 from diseased seals of Danish and Norwegian waters and isolates made in 1989 from distemper outbreaks in Danish mink farms. In contrast, the other distemper isolates investigated, including isolates from 1986 from a corresponding Danish mink farm, revealed the antigenic characteristics of CDV. Our results strongly indicate that PDV was recently transmitted from diseased seals to terrestrial carnivores causing distemper epizootics among farmed mink.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Appel MJG (1987) Canine distemper virus, In: Appel MJG (ed) Virus infections of vertebrates, vol 1; virus infections of carnivores. Elsevier, New York, pp 133–159

    Google Scholar 

  2. Appel MJG, Jones OR (1967) Use of alveolar macrophages for cultivation of canine distemper virus. Proc Soc Exp Biol Med NY 126: 571–574

    Google Scholar 

  3. Appel MJG, Shek WR, Shesberadaran H, Norrby E (1984) Measles virus and inactivated canine distemper virus induce incomplete immunity to canine distemper. Arch Virol 82: 73–82

    Google Scholar 

  4. Bengtson JL, Boveng P, Franzen U, Have P, Heide-Jørgensen MP, Härkönen TJ (1991) Antibodies to canine distemper virus in antarctic seals. Marine Mammal Sci 7: 85–87

    Google Scholar 

  5. Blixenkrone-Möller M (1989) Detection of intracellular canine distemper virus antigen in mink inoculated with an attenuated or a virulent strain of canine distemper virus. Am J Vet Res 50: 1616–1620

    Google Scholar 

  6. Blixenkrone-Möller M, Bohm J, Lund E (1989) Outbreak of distemper among sled dogs in Northern Greenland. In Danish: Udbrud af hundesyge blandt slädehunde i Nordgrönland. Dansk Vet Tidsskr 9: 488–497

    Google Scholar 

  7. Bixenkrone-Möller M, Svansson V, Have P, Bötner A (1989) Infection studies in mink with seal-derived morbillivirus. Arch Virol 106: 165–170

    Google Scholar 

  8. Blixenkrone-Møller M, Svansson V, Örvell C, Have P (1990) Phocid distemper virus — a threat to terrestrial mammals? Vet Rec 127: 263–264

    Google Scholar 

  9. Bohm J, Blixenkrone-Møller M, Lund E (1989) A serious outbreak of canine distemper among sled-dogs in Northern Greenland. Arct Med Res 48: 195–203

    Google Scholar 

  10. Cosby SL, McQuaid S, Duffy N, Lyons C, Rima BK, Allan GM, McCullough SJ, Kennedy S, Smyth JA, McNeilly F, Craig C, Örvell C (1988) Characterisation of a seal morbillivirus. Nature 336: 115–116

    Google Scholar 

  11. Curran MD, O'Loan D, Rima BK, Kennedy S (1990) Nucleotide sequence analysis of phocine distemper virus reveals its distinctness from canine distemper virus. Vet Rec 127: 430–431

    Google Scholar 

  12. Dietz R, Ansen TC, Have P, Heide-Jörgensen M-P (1989) Clue to seal epizootic? Nature 338: 627

    Google Scholar 

  13. Domingo M, Ferrer L, Pumarola M, Marco A, Plana J, Kennedy S, McAliskey, Rima BK (1990) Morbillivirus in dolphins. Nature 348: 21

    Google Scholar 

  14. Friedlander JM, Summers BA, Appel MJG (1985) Persistence of virulent canine distemper virus in lymphoblastoid cell lines. Arch Virol 86: 47–62

    Google Scholar 

  15. Grachev MA, Kumarev VP, Mamaev LV, Zorin VL, Baranova LV, Denikina NN, Belikov SI, Petrov EA, Kolesnik VS, Kolesnik RS, Dorofeev VM, Beim AM, Kudelin VN, Nagieva FG, Sidorov VN (1989) Distemper virus in Baikal Seals. Nature 338: 209

    Google Scholar 

  16. Hall WW, Lamb RA, Choppin PW (1980) The polypeptides of canine distemper virus: synthesis in infected cells and relatedness to the polypeptides of other morbilliviruses. Virology 100: 433–449

    Google Scholar 

  17. Hansen M, Lund E (1972) The protecting capacity of neutralizing antibodies by distemper virus infections in mink. Acta Pathol Microbiol Scand B 80: 795–800

    Google Scholar 

  18. Harder TC, Moennig V, Greiser-Wilke I, Barrett T, Liess B (1991) Analysis of antigenic differences between sixteen phocine distemper virus isolates and other morbilliviruses. Arch Virol 118: 261–268

    Google Scholar 

  19. Kennedy S, Smyth JA, Cush PF, McCullough SJ, Allan GM (1988) Viral distemper now found in porpoises. Nature 336: 21

    Google Scholar 

  20. Kennedy S, Smyth JA, McCullough SJ, Allan GM, McNeilly F (1988) Confirmation of recent seal deaths. Nature 335: 404

    Google Scholar 

  21. Krogsrud J, Evensen Ö, Holt G, Höie S, Markussen NH (1990) Seal distemper in Norway in 1988 and 1989. Vet Rec 126: 460–461

    Google Scholar 

  22. McCullough SJ, McNeilly F, Allan GM, Kennedy S, Smyth JA, Cosby SL, McQuaid S, Rima BK (1991) Isolation and characterization of a porpoise mobillivirus. Arch Virol 118: 247–252

    Google Scholar 

  23. Norrby E, Appel MJ (1980) Humoral immunity to canine distemper after immunization of dogs with inactivated and live measles virus. Arch Virol 66: 169–177

    Google Scholar 

  24. Norrby E, Sheshberadaran H, McCullough KC, Carpenter WC, Örvell C (1985) Is rinderpest the archevirus of the morbillivirus genus? Intervirology 23: 228–232

    Google Scholar 

  25. Norrby E, Utter G, Örvell C, Appel M (1986) Protection against canine distemper virus in dogs after immunization with isolated fusion protein. J Virol 58: 536–541

    Google Scholar 

  26. Osterhaus ADME, Groen J, de Vries P, UytdeHaag FCGM, Klingeborn B, Zarnke R (1988) Canine distemper virus in seals. Nature 335: 403–404

    Google Scholar 

  27. Osterhaus ADME, Vedder EJ (1988) Identification of a virus causing recent seal death. Nature 335: 20

    Google Scholar 

  28. Poste G (1971) The growth and cytopathogenecity of virulent and attenuated strains of canine distemper virus in dog and ferret macrophages. J Comp Pathol 81: 49–54

    Google Scholar 

  29. Sheshberadaran H, Norrby E, McCullough KC, Carpenter WC, Örvell C (1986) The antigenic relationship between measles, canine distemper and rinderpest viruses studied with monoclonal antibodies. J Gen Virol 67: 1381–1392

    Google Scholar 

  30. Sugiyama M, Minamoto N, Kinjo T, Hirayama N, Sasaki H, Yosikawa Y, Yamanouchi K (1989) Characterization of monoclonal antibodies against four structural proteins of rinderpest virus. J Gen Virol 70: 2605–2613

    Google Scholar 

  31. Trudgett A, Lyons C, Welsh MJ, Duffy N, McCullough SJ, Mc Neilly F (1991) Analysis of a seal and a porpoise morbillivirus using monoclonal antibodies. Vet Rec 128: 61

    Google Scholar 

  32. Vantis JT (1959) Preliminary note on the propagation of canine distemper virus in different tissue culture systems. Vet Rec 71: 99–100

    Google Scholar 

  33. Visser IKG, van de Bildt MWG, Brugge HN, Reijnders PJH, Vedder EJ, Kuiper J, de Vries P, Walvoort HC, UytdeHaag FGCM, Osterhaus ADME (1989) Vaccination of harbour seals (Phoca vitulina) against phocid distemper with two different inactivated canine distemper (CDV) vaccines. Vaccine 7: 521–526

    Google Scholar 

  34. Visser IK, Kumarev VP, Örvell C, De Vries P, Broeders HVJ, van de Bildt MWG, Groen J, Teppema JS, Burger MC, UytdeHaag FGC, Osterhaus ADME (1990) Comparison of two morbilliviruses isolated from seals during outbreaks of distemper in North-Western Europe and Siberia. Arch Virol 111: 149–164

    Google Scholar 

  35. Örvell C (1984) The reactions of monoclonal antibodies with structural proteins of mumps virus. J Immunol 132: 2622–2629

    Google Scholar 

  36. Örvell C, Blixenkrone-Möller M, Svansson V, Have P (1990) Immunological relationships between phocid and canine distemper virus studied with monoclonal antibodies. J Gen Virol 7: 2085–2092

    Google Scholar 

  37. Örvell C, Grandien M (1982) The effects of monoclonal antibodies on biologic activities of structural proteins of sendai virus. J Immunol 129: 2779–2787

    Google Scholar 

  38. Örvell C, Norrby E (1980) Immunological relationships between homologous structural polypeptides of measles and canine distemper virus. J Gen Virol 50: 231–245

    Google Scholar 

  39. Örvell C, Sheshberadaran H, Norrby E (1985) Preparation and characterization of monoclonal antibodies directed against four structural components of canine distemper virus. J Gen Virol 66: 443–456

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory for Virology and Immunology, Royal Veterinary and Agricultural University, Frederiksberg, Denmark

    M. Blixenkrone-Möller & V. Svansson

  2. The James Baker Institute for Animal Health, New York State College of Veterinary Medicine, Cornell University, Ithaca, New York, USA

    M. Appel

  3. National Veterinary Institute, Oslo, Norway

    J. Krogsrud

  4. State Veterinary Institute for Virus Research, Lindholm, Denmark

    P. Have

  5. Department of Virology, National Bacteriological Laboratory and Karolinska Institute, Stockholm, Sweden

    C. Örvell

Authors
  1. M. Blixenkrone-Möller
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. Svansson
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Appel
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. Krogsrud
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. P. Have
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. C. Örvell
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Blixenkrone-Möller, M., Svansson, V., Appel, M. et al. Antigenic relationships between field isolates of morbilliviruses from different carnivores. Archives of Virology 123, 279–294 (1992). https://doi.org/10.1007/BF01317264

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01317264

Keywords

Search

Navigation