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Experimental in vivo generation of intertypic recombinant strains of HSV in the mouse

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Summary

The primary replication of one strain of HSV was generally unaffected by the simultaneous inoculation of another strain either at the same site or at a different site within the same dermatome. Exceptions to this were the result of the generation of intertypic recombinants which were readily isolated only from sensory ganglia 5 and 6 days after inoculation with a mixture of HSV-1 and HSV-2 and from explant culture of the resultant latently infected ganglia. By restriction enzyme analysis the majority of the recombinant strains from primary infection were characterized as HSV 1; all those from latently infected ganglia were characterized as type 2.

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Authors and Affiliations

  1. Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol, UK

    D. L. Yirrell, C. E. Rogers, W. A. Blyth & T. J. Hill

  2. Department of Medical Microbiology, University of Edinburgh Medical School, Teviot Place, EH89AG, Edinburgh, Scotland

    D. L. Yirrell

Authors
  1. D. L. Yirrell
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  2. C. E. Rogers
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  3. W. A. Blyth
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  4. T. J. Hill
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Yirrell, D.L., Rogers, C.E., Blyth, W.A. et al. Experimental in vivo generation of intertypic recombinant strains of HSV in the mouse. Archives of Virology 125, 227–238 (1992). https://doi.org/10.1007/BF01309640

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  • DOI: https://doi.org/10.1007/BF01309640

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