Summary
The relationship of anticoagulant heparin was investigated with thrombotropin, prothrombokinase, thrombokinase and calcium.
It was demonstrated that heparin and thrombotropin are in antagonistic relationship.
Prothrombokinase and thrombokinase reduce the activity of heparin to the same extent.
Calcium chloride greatly decreases the activity of heparin introduced into the bloodstream.
Heparin introduced into the blood has no effect on the concentration of calcium salts in the blood.
The author considers that heparin exeris a powerful anticoagulant effect with compound action only in a pathological condition of the body when thrombogenic components which may directly cause the intravascular blood coagulation enter the bloodstream.
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Additional information
From the Laboratory (Director: Prof. B. A. Kudryashov). Chair of Biochemistry of Animals, Faculty of Biology and Soil Science, MGU
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Leikina, E.M. Significance of heparin in the process of blood coagulation. Bull Exp Biol Med 44, 1025–1028 (1957). https://doi.org/10.1007/BF01306820
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DOI: https://doi.org/10.1007/BF01306820