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Effect of omeprazole on gastric first-pass metabolism of ethanol

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Abstract

Some commonly used H2-receptor antagonists affect gastric first-pass metabolism of ethanol and lead to unexpectedly high blood alcohol concentrations after consumption of alcohol. To investigate whether omeprazole-a substituted benzimidazole recently approved for clinical use-has a similar harmful effect, we administered a moderate dose of ethanol (0.3 g/kg body wt) orally to seven normal volunteers before and after one week of omeprazole administration (20 mg daily). No significant effect of the drug was found on either mean peak blood alcohol concentrations or on areas under the blood alcohol curve; neither did these parameters differ significantly before or after an acute dose of omeprazole (13.2 mg/kg body wt) in rats, whether ethanol (0.25 g/kg body wt) was administered intragastrically or intravenously.In vitro, omeprazole in concentrations likely to occur in the gastric lumen (0.01–1.0 mM), did not affect gastric alcohol dehydrogenase activity of humans or rats. Thus omeprazole does not affect gastric first-pass metabolism of ethanol and can be considered as a safe choice for the treatment of patients who do not refrain from alcohol consumption during therapy.

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Authors and Affiliations

  1. Section of Liver Diseases and Nutrition and Alcohol Research and Treatment Center, Bronx Veterans Administration Medical Center and Mount Sinai School of Medicine, New York, New York

    Risto Roine, Rolando Hernández-Muñoz, Enrique Baraona, Robert Greenstein &  Charles S. Lieber

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  1. Risto Roine
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  2. Rolando Hernández-Muñoz
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  3. Enrique Baraona
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  4. Robert Greenstein
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  5. Charles S. Lieber
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Roine, R., Hernández-Muñoz, R., Baraona, E. et al. Effect of omeprazole on gastric first-pass metabolism of ethanol. Digest Dis Sci 37, 891–896 (1992). https://doi.org/10.1007/BF01300387

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  • DOI: https://doi.org/10.1007/BF01300387

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